Serotonin: all studies (page 111) - The Consciousness Library

Serotonin involvement in aversive conditioning: reversal of the fear retention deficit by long-term p-chloroamphetamine but not p-chlorophenylalanine.

Neuroscience Letters December 23, 1982 T Archer, S O Ogren, S B Ross 24 citations

5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), a serotonin (5-HT) agonist, fenfluramine and p-chloroamphetamine (PCA), which are 5-HT releasers, produce deficits in fear retention as indicated by a notable lack of the immobility resulting from inescapable shocks. Depletion of central 5-HT neurones after long-term PCA treatment (2 X 10 mg/kg) completely blocked the retention impairment resulting...

DOI: 10.1016/0304-3940(82)90095-7 Full text

Inhibition of prolactin release by stimulation of presynaptic serotonin autoreceptors.

Life Sciences December 6, 1982 J A Clemens, M E Roush 8 citations

The effects of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), a serotonin agonist with a preferential action on presynaptic autoreceptors, on prolactin release in male rats was determined. Basal serum prolactin levels were not altered after administration of 1.0, 2.0, 5.0, 10.0 or 20.0 mg/kg of 5-MeODMT. Pretreatment with 5-MeODMT reduced prolactin release by agents that depend on serotonergic...

DOI: 10.1016/0024-3205(82)90740-8 Full text

Drug interactions do not support reduction in serotonin turnover as the mechanism of action of benzodiazepines.

Neuropharmacology October 1, 1982 R A Shephard, D A Buxton, P L Broadhurst 59 citations

Interactions between 5-methoxy, N,N-dimethyltryptamine (5-MeODMT), chlordiazepoxide and para-chlorophenylalanine (pCPA) on conflict behaviour were studied. 5-Methoxy, N,N-dimethyltryptamine (1.0 and 3.0 mg/kg), induced observable effects and reduced unpunished response rates but did not affect punished behaviour either alone, on in the presence of 5 or 10 mg/kg chlordiazepoxide. However,...

DOI: 10.1016/0028-3908(82)90117-4 Full text

Serotoninergic agents in the treatment of isolated sleep paralysis.

American Journal of Psychiatry September 1982 S Snyder, G Hams

The authors report three cases of isolated sleep paralysis controlled by L-tryptophan with or without amitriptyline. Both agents increase CNS 5-hydroxytryptamine availability, whereas imipramine, which was ineffective in the one case in which it was tried, affects predominantly norepinephrine reuptake.

DOI: 10.1176/ajp.139.9.1202 Full text

8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT-receptor stimulating activity

Journal of Neural Transmission September 1, 1982 S. Hjorth, A. Carlsson, P. Lindberg et al.

It was demonstrated that the simplified ergot congener 8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, is able to elicit pronounced biochemical and behavioural alterations indicative of central serotoninomimetic activity. Since these effects are resistant to prior monoamine depletion and/or synthesis inhibition by means of reserpine and α -propyldopacetamide (H22/54), respectively, they are...

DOI: 10.1007/bf01276574 Full text 8-hydroxy-2-di-n-propylaminotetralin Ergot congen

Medullary serotonergic neurons are insensitive to 5-MeoDMT and LSD.

European Journal of Pharmacology July 30, 1982 J Heym, G F Steinfels, Barry L. Jacobs 21 citations

A comparison was made of the effects of 5-MeoDMT or LSD on serotonergic unit activity in the dorsal raphe nucleus (DRN) and nucleus raphe pallidus (NRP) of freely moving cats. NRP neurons were substantially less responsive than DRN neurons to both drugs. NRP neurons were unresponsive to behaviorally effective low doses of these drugs whereas the activity of DRN neurons was strongly depressed....

DOI: 10.1016/0014-2999(82)90360-0 Full text LSD Psychedelics 5-meodmt Psychedelic compounds +20

Citalopram antagonizes the stimulation by lysergic acid diethylamide of presynaptic inhibitory serotonin autoreceptors in the rat hypothalamus.

Journal of Pharmacology and Experimental Therapeutics July 1, 1982 Salomón Z. Langer, Chantal Moret 100 citations

Slices of rat hypothalamus prelabeled with [3H]-5-hydroxytryptamine ([3H]-5-HT) were superfused and the release of the labeled transmitter was elicited either by electrical stimulation or by fenfluramine. Whereas the electrically stimulated release of [3H]-5-HT was completely abolished by removing calcium from the superfusion medium, the fenfluramine-induced release of [3H]-5-HT was...

DOI: 10.1016/s0022-3565(25)33177-0 Lysergic acid diethylamide Serotonin Serotonergic Autoreceptor +10

Effects of certain hallucinogenic amphetamine analogs on the release of [3H]-serotonin from rat brain synaptosomes

Journal of Medicinal Chemistry May 1, 1982 David E. Nichols, David Harley Lloyd, Andrew J. Hoffman et al. 178 citations

The enantiomers of 3,4-(methylenedioxy)amphetamine (MDA), p-methoxyamphetamine (PMA), and N-Me-MDA (MDMA), along with their alpha, alpha-dimethylated derivatives, were evaluated for an effect on the release of [3H]serotonin from rat whole brain synaptosomes. The amphetamine isomers were all potent in inducing the release of [3H]serotonin at bath concentrations of 1 and 10 micrometers but were...

DOI: 10.1021/jm00347a010 MDMA Citation Amphetamine

Effects of diazepam and of serotonin agonists on hyponeophagia in rats.

Neuropharmacology April 1, 1982 R A Shephard, P L Broadhurst 53 citations

The effects of serotonin agonists, fenfluramine (2 mg/kg) and 5-methoxy N,N dimethyltryptamine (5-MeODMT, 2.5 mg/kg) on hyponeophagia were studied both alone and in combination with diazepam (1 mg/kg). Male and female rats were used but sex differences were not found. The serotonin agonists enhanced hyponeophagia while diazepam attenuated it and antagonised the actions of both serotonin...

DOI: 10.1016/0028-3908(82)90097-1 Full text

Inhibition of phrenic and sympathetic vasomotor neurons in cats by the serotonin analog 5-methoxy-N,N-dimethyltryptamine.

Journal of Pharmacology and Experimental Therapeutics March 1, 1982 P. Lalley

5-Methoxy-N,N-dimethyltryptamine (20-200 microgram/kg) inhibits phrenic and sympathetic neural discharges and depresses blood pressure. The effects occur within seconds after injection. Complete recovery occurs, on the average, after 20 min. The inhibition of phrenic nerve discharges is prevented during hypercapnia and hyperthermia and reversed during 50 Hz electrical stimulation of the carotid...

DOI: 10.1016/s0022-3565(25)32894-6

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