Effects of chronic administration of antidepressant drugs on central serotonergic receptor mechanisms
Sven Ove Ögren, Kjell Fuxé, Odd‐geir Berge, Luigi F Agnati
Palgrave Macmillan UK eBooks 1983 DOI: 10.1007/978-1-349-06689-6_7 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | desipramine imipramine zimelidine |
| Duration | Chronic treatment |
| Topics | Serotonin |
| Keywords | Desipramine Imipramine Antidepressant Pharmacology 5-HT Receptor Serotonin agonist Partial agonist |
| Citations | 11 |
| Key points | Chronic antidepressant treatment with desipramine, imipramine, and zimelidine produced both sub- and supersensitivity to serotonin agonists, depending on agonist dose and the behavioral measure, with zimelidine generally decreasing net 5-HT activity. |
Abstract
The present studies have shown that chronic antidepressant treatment with desipramine (DMI), imipramine (IMI) and zimelidine produced behavioral evidence for sub- and supersensitivity depending on 5-HT agonist dose and types of behavior examined. Thus, chronic treatment with all three drugs reduced head twitches induced by a high dose of the 5-HT agonist 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT, 4 mg/kg) while an enhanced response was observed at a low 5-MeO-DMT dose (1 mg/kg) or a low dose of the 5-HT precursor 1-5-hydroxytryptophan (12.5 mg/kg). Chronic ZIM and IMI treatment tended to enhance 5-HT receptor activity as assessed by the induction of hyperlocomotion by a high 5-MeO-DMT dose (4 mg/kg) while they reduced the effect of a low dose (1 mg/kg). Long-term ZIM treatment gave evidence of behavioral subsensitivity to the 5-HT agonist 5-MeO-DMT in avoidance learning, while an enhanced response to 5-MeO-DMT was observed in the tail-flick model. However, chronic ZIM treatment shortened response latency in the tail-flick model suggesting that the net result is a decrease in 5-HT activity.
Comparable studies
Other preclinical and animal studies on serotonin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context) | 1987 | Experimental study | |
| Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors In vitro and in vivo (rodent) models | 2023 | Experimental study | |
| 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain | 1987 | Animal experiment | |
| Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells | 2006 | In vitro laboratory study |