Room temperature fluorometric and low-temperature phosphorimetric analytical curves of hallucinogens in methanol/water solution have been prepared to demonstrate the absence of interference in common binary mixtures of hallucinogenic drugs. Limits of detection and linear dynamic ranges have been determined for drugs in mixtures. Mixtures containing LSD and another hallucinogen such as STP...
IN attempts to work out possible mechanisms of action of the hallucinogenic drugs, it would be helpful to know which chemical groups modify their activity. In the methoxylated amphetamines, some methoxy groups may act as electrostatic binding sites and some may effect the shape and energy distribution of the π cloud. It may also be important to know whether the amino group is necessary for...
1. DeShon, Rinkel & Solomon, Mental Changes Experimentally Produced by LSD, 26 PSYCHIAT.Q. 33 (1952).2. Stoll & Hofmann, Partialsynthese von AlkalZiden vom Typus des Ergobasins, 26 HELvET.CHim.AcmA.944 (1943).See Laughlin, LSD-25 and the Other Hallucinogens: A Pe-Reform Proposal, 36 GEo.WAsH.L. REv. 23, 27 n.23 (1967), for a brief discussion of the history and sources of the other...
OUT ON A (PHANTOM) LIMB VARIATIONS ON THE THEME: STABILITY OF BODY IMAGE AND THE GOLDEN SECTION And man created God in his own body image. ROLAND FISCHER* Psychodysleptic Drug-inducedInterference with Readaptation to Distortions It is by now well known that wearing prism spectacles results in a variety ofperceptual distortions which, however, gradually disappear within a period oftime [i, 2,...
Abstract Physical characteristics are reported for a tablet form of a new hallucinogenic drug previously circulating in the USA under the name “STP”. High resolution mass, nmr, ultraviolet and infrared spectrometric evidence, which identify the extracted base as 2,5-dimethoxy-4-methylamphetamine, and its chromatographic behaviour, are compared with the experimental compound “DOM”. Polymorphic...
THE PUBLIC has become aware of the increasing use of the major psychedelic substances (lysergic acid diethylamide [LSD], peyote, psilocybin, morning glory seeds) by certain individuals outside the contexts of supervised therapy and research.1,2Several excellent clinical studies have firmly documented the hazards of this Practice.4,5At a time when the scientific community has been gathering...
The metabolism of C 14 -labeled β-(3,4-dimethoxyphenyl)ethylamine (DMPEA), reported to be present in the urine of several patients with mental disorders, was studied in man after oral administration. The cumulative excretion of radioactivity in the urine and the concentration of the radioactive material in plasma and cerebrospinal fluid were determined. Unchanged DMPEA,...
Based on the frequently reported similarities between creative and psychedelic (drug-induced, consciousness-expansion) experiences, a preliminary study was conducted to explore the effects of psychedelic agents (LSD-25, mescaline) on creative problem-solving ability. Twenty-seven professionally employed males were given a single psychedelic experience in 1 of 7 small groups ( ns = 3 or 4)...
The use of hallucinogenic (psychotomimetic, dysleptic, psychedelic) substances to produce altered states of consciousness is not new,1-3but recently there has been increased interest and publicity given these agents. This renewed attention has been spurred by the discovery of several new substances, such as d-lysergic acid diethylamide (LSD), psilocybin, and psilocin, which have potencies far...
Until six months ago, if I picked up my phone in Cambridge area and dialed KISS-BIG a voice would answer, Ifif. These were coincidences: KISS-BIG simply happened to be letter equivalents of an arbitrarily assigned telephone number, while I.F.I.F. represented initials of an organization with improbable name of International Federation for Internal Freedom. But coincidences were apposite to point...