Pharmacology, Biochemistry, and Behavior
October 2007
Danuta Marona‐lewicka, David E Nichols
Activation of 5-HT(2A) receptors is thought to mediate the hallucinogenic effects of LSD. Nevertheless, in a previous report we provided evidence that a delayed temporal phase of the behavioral pharmacology of LSD is mediated by D(2)-like dopamine receptor stimulation. In this study rats were trained to discriminate LSD with either a 30 min preinjection time (LSD-30, N=12) or a 90 min...
Pharmacology, Biochemistry, and Behavior
October 1, 2007
Jerrold C Winter, K C Rice, D J Amorosi et al.
73 citations
Although psilocybin has been trained in the rat as a discriminative stimulus, little is known of the pharmacological receptors essential for stimulus control. In the present investigation rats were trained with psilocybin and tests were then conducted employing a series of other hallucinogens and presumed antagonists. An intermediate degree of antagonism of psilocybin was observed following...
Plains Anthropologist
May 1, 2007
William C. Meadows, Kenny Harragarra
3 citations
Ten color drawings made by Gotebo, a Kiowa, around 1914 chronicle several of the major cultural and religious experiences and transitions in his life from the pre-reservation period into the early twentieth century. Focusing on the period between circa 1865 to the 1890s, the drawings illustrate his experiences as a warrior, his first two marriages, and his religious participation in the Sun...
Drug and Alcohol Dependence
March 16, 2007
Andrea L Stone, Megan S O'Brien, Alejandro De la Torre et al.
This study, based upon epidemiological survey data from the United States (U.S.) National Household Surveys on Drug Abuse (NHSDA) from 2000 to 2001, presents new estimates for the risk of developing a hallucinogen dependence syndrome within 24 months after first use of any hallucinogen (median elapsed time approximately 12 months). Subgroup variations in risk of becoming hallucinogen dependent...
Neuron
February 1, 2007
Javier González-Maeso, Noelia V Weisstaub, Mingming Zhou et al.
Hallucinogens, including mescaline, psilocybin, and lysergic acid diethylamide (LSD), profoundly affect perception, cognition, and mood. All known drugs of this class are 5-HT(2A) receptor (2AR) agonists, yet closely related 2AR agonists such as lisuride lack comparable psychoactive properties. Why only certain 2AR agonists are hallucinogens and which neural circuits mediate their effects are...
The Journal of Organic Chemistry
December 29, 2006
Dino Alberico, Alena Rudolph, Mark Lautens
60 citations
A norbornene-mediated palladium-catalyzed sequence is described in which two alkyl-aryl bonds and one alkenyl-aryl bond are formed in one pot with use of microwave irradiation. A variety of symmetrical and unsymmetrical oxygen-, nitrogen-, silicon-, and sulfur-containing tricyclic heterocycles were synthesized from a Heck acceptor and an aryl iodide containing two tethered alkyl halides. This...
October 18, 2006
Arthur J. Magida
This chapter tries to chart the degree of religiosity at which saturation creeps in and has attritions effects. Quite paradoxically, the subject of inquiry, Huston Smith, an erstwhile practitioner of all religions, literally, and a consequential religious scholar, does not display any trace of exhaustion after reaching an objective point of saturation—he has meditated with Zen masters in Japan,...
Afrique & histoire
September 15, 2006
Patricia A. Helvenston, Paul G. Bahn
1 citation
Résumé Cet article oppose une série de contradictions au modèle neuropsychologique dit des Trois Stades de la Transe (TST) proposé par Lewis-Williams et Dowson, modèle dont la popularité excède de loin la solidité de ses fondations empiriques. Lewis-Williams et Dowson ont écrit comme si le modèle TST avait été vérifié en Afrique du Sud, mais ce n’est pas le cas, ainsi que nous le montrons par...
Journal of Neurochemistry
November 8, 2005
Jason C. Parrish, Michael R Braden, Emily Gundy et al.
40 citations
Experiments compared a series of phenethylamine hallucinogens with their phenylisopropylamine analogues for binding affinity and ability to stimulate serotonin 5-HT 2A receptor-mediated hydrolysis of phosphatidyl inositol in cells expressing cloned rat and human 5-HT 2A receptors. The (+/-)phenylisopropylamine analogues had significantly higher intrinsic activities for 5-HT 2A receptor-mediated...
Journal of Emergency Medicine
November 2005
Manish M Patel, Martin G Belson, Adam B Longwater et al.
MDMA (or 3, 4 methylenedioxymethamphetamine) was first manufactured in the 1920s and found to have structural similarities to both mescaline and amphetamines. Used briefly by some therapists in the 1970s and early 1980s as an adjunct to psychotherapy, it is now primarily abused by teenagers and young adults as an illicit recreational drug known as "ecstasy." As its popularity has increased, so...