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Psychiatric Annals March 1, 1994 Robert L. Dupont, Karl Verebey 1 citation
LSD and Ecstasy and other hallucinogenic drugs (especially psilocybin mescaline) are in an anomalous position as frequently abused, widely available illicit drugs that are rarely identified in drug tests.
Journal of Psychoactive Drugs 1994 Thomas J. Riedlinger, June E. Riedlinger 39 citations
CNS deficiency of 5-hydroxytryptamine (serotonin) has been implicated as a biochemical basis in some forms of depression. Existing drug modalities for treating depression include some with serotonergic effects. Studies suggest that psychedelic drugs are also serotonergic. This may indicate a role for psychedelics in the treatment of depression. Such treatment has already been attempted using...
Psychopharmacology March 1, 1990 Lauren L. Wing, Gregory S. Tapson, Mark A. Geyer 99 citations
In rats tested during their first exposure to a Behavioral Pattern Monitor chamber, acute injections of the 5HT-2 agonists mescaline, quipazine, 2,5-dimethoxy-4-iodoamphetamine (DOI), 2,5-dimethoxy-4-methylamphetamine (DOM), or 2,5-dimethoxy-4-ethylamphetamine (DOET) produced an inhibition of locomotor and investigatory behavior during the first 30 min of the test session. This suppression of...
Comprehensive Psychiatry September 1, 1989 A Harrington, G Oepen, M Spitzer
Three disorders of facial recognition and perception in acute schizophrenia and mescaline-induced psychosis are described and illustrated using original clinical and experimental material: "affective prosopagnosia" or stress-related dysfunctional face recognition; "physiognomization" of the environment or persistent illusions and hallucinations of nonspecific faces; and the "mirror phenomenon"...
Journal of Psychoactive Drugs 1989 Gary Bravo, Charles S. Grob 38 citations
This article reviews the role of psychedelic drugs as potential tools for psychiatric research and practice. The decline in the utilization of these substances is linked to social reactions, which led to psychedelics being scheduled as controlled substances and consequently unavailable for human research. Three different paradigms for the use of psychedelics in psychiatry are reviewed: the...
Journal of Pharmacology and Experimental Therapeutics September 1, 1988 P M Callahan, J B Appel
The stimulus properties of 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA) and several related compounds were compared to those of (+)-lysergic acid diethylamide (LSD) and mescaline (3,4,5-trimethoxyphenylethylamine) in a two-lever, water-reinforced, drug discrimination task. In animals trained to discriminate LSD (0.08 mg/kg) from saline (n = 8), LSD-like...
Brain Research October 1, 1986 K Rasmussen, George K. Aghajanian
As previously reported, systemic administration of the hallucinogens D-lysergic acid diethylamide (LSD) (5-10 micrograms/kg) and mescaline (2 mg/kg) in the anesthetized rat produced a decrease in spontaneous activity but, paradoxically, facilitated activation of locus coeruleus (LC) neurons by sciatic nerve stimulation. In the present study, the hallucinogen 2,5-dimethoxy-4-methylamphetamine...
Archives of Disease in Childhood March 1, 1985 I A Auchterlonie, B. Benjamin 2 citations
1141 Objectives: The ayahuasca effect refers to the potentiation of action of hallucinogenic tryptamine alkaloids by co-administration of a plant extract containing MAO inhibitors, especially the beta-carboline harmine. The hallucinogenic tryptamines in the ayahuasca drink are primarily DMT and 5-MeO-DMT, the same tryptamines in extracts of Bufo skin, and the snuff yopo, another South American...
Psychiatric Clinics of North America December 1, 1984 S Cohen
The hallucinogenic drugs represent a recurrent outbreak pattern with each generation or two seeming to rediscover their ego-dissolving effects. The inhalants produce a short-lived intoxication with certain volatile solvents affecting specific organ systems.
Journal of Medicinal Chemistry September 1, 1984 David E. Nichols, K. P. Jadhav, Robert Oberlender et al. 12 citations
cis- and trans-2-(2,4,5-trimethoxyphenyl)cyclobutylamine and trans-2-(2,5-dimethoxy-4-methylphenyl)cyclobutylamine were synthesized as conformationally restricted analogues of hallucinogenic phenylisopropylamines. In rats trained to discriminate saline from LSD (0.08 mg/kg, ip) in a two-lever drug discrimination paradigm, no generalization of the LSD stimulus to the cis trimethoxy compound...