5HT-2 mediation of acute behavioral effects of hallucinogens in rats
Psychopharmacology March 1, 1990 Lauren L. Wing, Gregory S. Tapson, Mark A. Geyer 99 citations
In rats tested during their first exposure to a Behavioral Pattern Monitor chamber, acute injections of the 5HT-2 agonists mescaline, quipazine, 2,5-dimethoxy-4-iodoamphetamine (DOI), 2,5-dimethoxy-4-methylamphetamine (DOM), or 2,5-dimethoxy-4-ethylamphetamine (DOET) produced an inhibition of locomotor and investigatory behavior during the first 30 min of the test session. This suppression of...