Objective Charles Bonnet syndrome (CBS) refers to the presence of visual hallucinations occurring secondary to visual impairment. The aim of this study was to understand the phenomenology of CBS in children and assess the emotional impact and support needs of patients and their families. Design Semistructured qualitative interview study. Setting UK. Participants Children (7–15 years) with an...
Introduction: An overview is given on the use of microdosing/microtracing studies for the safer and faster development of drugs in children. In a microdosing study a very small amount of radiolabelled (often 14C) drug is administered to a human volunteer. Using accelerator mass spectrometry extremely low amounts of the drug and metabolites can be traced and quantified. Methods: Several...
The first breaths of air have since antique time been regarded as the ignition of life as indicated by the word spirits. The newborn becomes animated in this way – i.e. the emergence of consciousness. In modern time a bioethics committee1 has stated that when the new-born encompasses the capacity to breathe either independently, or with the support of a ventilator is the moral and legal point...
1141 Objectives: The ayahuasca effect refers to the potentiation of action of hallucinogenic tryptamine alkaloids by co-administration of a plant extract containing MAO inhibitors, especially the beta-carboline harmine. The hallucinogenic tryptamines in the ayahuasca drink are primarily DMT and 5-MeO-DMT, the same tryptamines in extracts of Bufo skin, and the snuff yopo, another South American...