European Journal of Pharmacology
November 15, 1977
Om D. Gulati, Nandkumar S. Shah
The amine releasing action of mescaline was investigated in rat isolated hypothalamus labeled with 3H-metaraminol. Mescaline had no effect on the uptake of 3H-metaraminol but produced its release in a concentration-related manner. 4 x 10(-4) M mescaline, which produced submaximal effects was used for subsequent experiments. 3 x 10(-5) M cocaine had no effect on the 3H-metaraminol releasing...
Neurochemical Research
June 1, 1977
Nandkumar S. Shah, O. D. Dulati, D. A. Powell et al.
2 citations
Albino rabbits of either sex were anesthetized, and a cannula was implanted permanently into the lateral ventricle. About 1 week later, the distribution of [(14)C]mescaline and its deaminated metabolite, [(14)C]trimethoxyphenylacetic acid ([(14)C]TMPA) in 12 brain regions was examined at 15, 60, and 180 min after the intraventricular injection of [(14)C]mescaline (0.5 μmol in 0.05 ml...
Drug Metabolism and Disposition
March 1, 1975
Nandkumar S. Shah, Kanhaiya R. Shah, R.s. Lawrence et al.
6 citations
Rats of 1,4,8,12,20, and 60 days postnatal age were injected ip with 14-C-mescaline (50 nCi/g). The levels of mescaline and its deaminated metabolite, 3,4,5-trimethoxyphenylacetic acid, were examined in the brain, liver, heart, spleen, lung, and kidney at 30, 60, 90, and 120 min. Mescaline was rapidly taken up by all the organs examined. In general, the organs of younger rats accumulated much...
Pharmacology
1975
Nandkumar S. Shah, Om D. Gulati
Incubation of rat brain homogenates or 14,500 g pellet isolated from the homogenate with (14C)-mescaline was associated with accumulation of (14C)-mescaline in the pellet. 1.33 mumol/ml of chlorpromazine, trifluoperazine, fluphenazine, imipramine, desmethylimipramine, nortriptyline and amitriptyline inhibited the accumulation of mescaline. Lower concentrations (0.133-0.44 mumol/ml) of the...