Lysergic Acid Diethylamide (LSD): No Teratogenicity in Rats
Science February 16, 1968 DOI: 10.1126/science.159.3816.731 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Sample size | 89 |
| Population | Pregnant rats |
| Intervention | Lysergic acid diethylamide (LSD) |
| Dose | 1.5 to 300 micrograms |
| Topics | LSD |
| Keywords | Pregnancy Teratology Organogenesis Physiology Pharmacology Endocrinology Gestation |
| Citations | 55 |
| Key findings | LSD did not produce a greater frequency of congenital defects in rat offspring than in controls. |
Abstract
Lysergic acid diethylamide (LSD) in doses of 1.5 to 300 micrograms was given to 55 pregnant rats during periods of organogenesis and on the 4th or 5th day of pregnancy to 34 rats. Examination of the resultant 887 young for congenital defects showed no greater frequency than in controls. These experiments failed to prove that LSD is teratogenic in rats.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 10
- LSD and Genetic Damage Science April 30, 1971
- Treatment of alcoholism using psychedelic drugs: a review of the program of research. Journal of Psychoactive Drugs 1998
- LSD and Chromosomes JAMA November 3, 1969
- Does LSD induce chromosomal damage and malformations? A review of the literature Teratology August 1, 1972
- Effect of LSD on Human Pregnancy JAMA June 1, 1970
and 5 more in the library
Cites 3
- Chromosomal Damage in Human Leukocytes Induced by Lysergic Acid Diethylamide Science March 17, 1967
- Lysergic Acid Diethylamide: Effect on Embryos Science September 15, 1967
- Congenital Malformations Induced by Mescaline, Lysergic Acid Diethylamide, and Bromolysergic Acid in the Hamster Science October 13, 1967