In Vivo and in Vitro Chromosomal Damage Induced by LSD-25
Maimon M. Cohen, Kurt Hirschhorn, William A. Frosch
New England Journal of Medicine November 16, 1967 DOI: 10.1056/nejm196711162772001 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Sample size | 6 |
| Population | Normal, healthy persons (3 males and 3 females) |
| Intervention | Lysergic acid diethylamide (LSD-25) |
| Topics | LSD |
| Keywords | In vitro In vivo Psychotomimetic Hallucinogen Antineoplastic drugs Pharmacology Genetic neurodegenerative diseases |
| Citations | 150 |
| Key findings | LSD-25 induces chromosomal aberrations in human leukocytes. |
Abstract
THE induction of chromosomal aberrations by exogenous agents, such as viruses, radiation and chemicals, is an area of active cytogenetic investigation.1 Recently, the psychotomimetic hallucinogen, lysergic acid diethylamide (LSD-25), has been added to the list of chemicals capable of causing abnormalities in the chromosomes of human leukocytes.2 , 3 Such preliminary studies report the in vitro and in vivo chromosomal effects of LSD, and the present communication extends these observations to include additional in vitro findings and a significant sample of patients.Materials and MethodsIn Vitro StudiesPeripheral leukocyte cultures were initiated from 6 normal, healthy persons (3 males and 3 . . .
Comparable studies
Other observational and cohort studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Human participants | 2016 | Observational cohort | |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants | 2018 | Observational study with computational modeling |
Citations in the library
Cited by 25
- Human hallucinogen research: guidelines for safety. Journal of Psychopharmacology July 1, 2008
- The Experimental Use of Psychedelic (LSD) Psychotherapy JAMA June 15, 1970
- LSD and Genetic Damage Science April 30, 1971
- Treatment of alcoholism using psychedelic drugs: a review of the program of research. Journal of Psychoactive Drugs 1998
- Lysergic Acid Diethylamide New England Journal of Medicine February 22, 1968
and 20 more in the library
Cites 4
- Chromosomal Damage in Human Leukocytes Induced by Lysergic Acid Diethylamide Science March 17, 1967
- Chromosomal Abnormalities in Leukocytes from LSD-25 Users Science July 21, 1967
- Untoward Reactions to Lysergic Acid Diethylamide (LSD) Resulting in Hospitalization New England Journal of Medicine December 2, 1965
- Lysergic Acid Diethylamide: Effect on Embryos Science September 15, 1967