LSD: Autoradiographic Study on the Placental Transfer and Tissue Distribution in Mice
Juhana E. Idänpään-heikkilä, Joseph C. Schoolar
Science June 13, 1969 DOI: 10.1126/science.164.3885.1295 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Pregnant subjects (early and late stage pregnancy) |
| Intervention | 14 C-lysergic acid diethylamide administered intravenously |
| Topics | LSD |
| Keywords | Fetus Placenta Distribution mathematics Endocrinology Excretion Lysergic acid Pregnancy Biochemistry |
| Citations | 32 |
| Key findings | Lysergic acid diethylamide rapidly distributes to multiple organs and crosses the placental barrier, with higher transfer in early versus late pregnancy. |
Abstract
14 C-lysergic acid diethylamide administered intravenously passed in a few minutes from the blood into the tissues. In addition to the brain, the adrenals, hypophysis, kidneys, liver, and lungs showed the highest uptake, much higher than the blood concentration. Excretion into the bile started immediately; this was the most important elimination route. In the early stage of pregnancy, 2.5 percent (and in the late stage, 0.5 percent) of the radioactive dose passed the placental barrier into the fetus in 5 minutes. Over 70 percent of this fetal radioactivity was unchanged 14 C-lysergic acid diethylamide.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 5
- LSD and Genetic Damage Science April 30, 1971
- Metabolism of lysergic acid diethylamide (LSD): an update Drug Metabolism Reviews July 3, 2019
- Does LSD induce chromosomal damage and malformations? A review of the literature Teratology August 1, 1972
- Genetic toxicology of lysergic acid diethylamide (LSD-25) Mutation Research/Reviews in Genetic Toxicology 1977
- Autoradiographic studies on the distribution of 3H-mescaline in the brain of the marmoset, Callithrix jacchus Psychopharmacology 1976
Cites 5
- Chromosomal Damage in Human Leukocytes Induced by Lysergic Acid Diethylamide Science March 17, 1967
- THE DISTRIBUTION AND METABOLISM OF LYSERGIC ACID DIETHYLAMIDE Annals of the New York Academy of Sciences March 1, 1957
- Chromosomal Abnormalities in Leukocytes from LSD-25 Users Science July 21, 1967
- Congenital Malformations Induced by Mescaline, Lysergic Acid Diethylamide, and Bromolysergic Acid in the Hamster Science October 13, 1967
- Lysergic Acid Diethylamide: Mutagenic Effects in Drosophila Science September 6, 1968