Comparison of the Chromosomal Patterns Obtained from Groups of Continued Users, Former Users, and Nonusers of LSD-25
Lewis L. Judd, W.w. Brandkamp, William H. Mcglothlin
American Journal of Psychiatry November 1, 1969 DOI: 10.1176/ajp.126.5.626 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Single-blind study Longitudinal Peer reviewed |
|---|---|
| Sample size | 25 |
| Population | Heavy users of LSD-25 (current and former) and drug-free control subjects |
| Topics | LSD |
| Keywords | Chromosome Ingestion Population Physiology Genetics |
| Citations | 16 |
| Key points | No significant differences in chromosome breakage rates were found between heavy LSD users and drug-free controls, with mean breakage rates of 1.8% or less across all groups. |
Abstract
In a single-blind study chromosome analyses were performed on three groups of subjects: 1) nine heavy users of LSD-25 who have continued to use the drug; 2) eight heavy users of LSD-25 who have ceased to use it; and 3) eight drug-free control subjects. The results revealed no significant differences in chromosome break-age rates between any of the three groups and therefore no temporal factor was elicited regarding chromosome damage and LSD ingestion. The mean breakage rates for all three groups were 1.8 percent or less and did not support earlier findings that LSD ingestion causes an increase in chromosome aberrations over those observed in a normal control population. The authors emphasize the need for a more controlled longitudinal study.
Comparable studies
Other randomized controlled trials on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases Patients with anxiety associated with life-threatening diseases | 2014 | Randomized controlled trial | n = 12 |
| Dose-Response Study of N,N-Dimethyltryptamine in Humans Experienced hallucinogen users | 1994 | Double-blind, saline placebo-controlled, randomized study | n = 12 |
| Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects Healthy subjects (8 women, 8 men) | 2014 | Double-blind, randomized, placebo-controlled, crossover study | n = 16 |
| Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor Healthy human participants | 2018 | Double-blind, randomized, counterbalanced, cross-over study | n = 24 |
| LSD-induced entropic brain activity predicts subsequent personality change. Healthy adults | 2016 | Balanced-order, placebo-controlled study | n = 19 |
Citations in the library
Cited by 5
- LSD and Genetic Damage Science April 30, 1971
- Treatment of alcoholism using psychedelic drugs: a review of the program of research. Journal of Psychoactive Drugs 1998
- Does LSD induce chromosomal damage and malformations? A review of the literature Teratology August 1, 1972
- Genetic toxicology of lysergic acid diethylamide (LSD-25) Mutation Research/Reviews in Genetic Toxicology 1977
- Is psychedelic use associated with cancer?: Interrogating a half-century-old claim using contemporary population-level data Journal of Psychopharmacology August 16, 2022
Cites 5
- Chromosomal Damage in Human Leukocytes Induced by Lysergic Acid Diethylamide Science March 17, 1967
- In Vivo and in Vitro Chromosomal Damage Induced by LSD-25 New England Journal of Medicine November 16, 1967
- Chromosomal Abnormalities in Leukocytes from LSD-25 Users Science July 21, 1967
- Leukocytes of Humans Exposed to Lysergic Acid Diethylamide: Lack of Chromosomal Damage Science October 27, 1967
- Chromosomal Damage in LSD Users JAMA April 15, 1968