Lysergic Acid Diethylamide and Stimulus Generalization: Rate-Dependent Effects
Linda A. Dykstra, James B. Appel
Science August 25, 1972 DOI: 10.1126/science.177.4050.720 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | LSD |
| Topics | LSD |
| Key findings | LSD changed the shape of the auditory generalization gradient only at a dose that decreased relatively high response rates, indicating that the drug's effect on stimulus sensitivity may be secondary to its rate-suppressing action. |
Abstract
A stimulus generalization procedure was used to investigate the effects of LSD on sensitivity to auditory stimuli in rats. The shape of the generalization gradient was changed after administration of the drug only with a dose which produced decreases in relatively high rates of responding.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 3
- Effects of LSD, DMT and psilocybin on cognitive and psychological functions: A systematic review of the literature Journal of Psychopharmacology February 16, 2026
- Psychedelic drugs and perception: a narrative review of the first era of research Reviews in the Neurosciences February 5, 2021
- The effect of drugs on the acquisition of stimulus control in a conditioned suppression procedure. Psychopharmacology 1985