Molecular Structure of LSD
Roy W. Baker, Cyrus Chothia, Peter Pauling, Hans Peter Weber
Science November 10, 1972 DOI: 10.1126/science.178.4061.614 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Crystallographic study Peer reviewed |
|---|---|
| Topics | LSD |
| Keywords | Steric effects Hallucinogen Stereochemistry Crystallography |
| Citations | 23 |
| Key points | LSD's molecular configuration in crystals of the iodobenzoate shows strain, steric hindrance, and a fixed conformation. |
Abstract
The molecular configuration of lysergic acid diethylamide (LSD) in crystals of the iodobenzoate has been determined by using x-ray diffraction techniques. The configuration shows strain and steric hindrance and the conformation is fixed. Some of the implications of this for the hallucinogenic activity of LSD are discussed.
Citations in the library
Cited by 5
- Crystal structure of an LSD-bound human serotonin receptor Cell January 26, 2017
- Psilocybin: from ancient magic to modern medicine The Journal of Antibiotics May 12, 2020
- Lysergamides of Isomeric 2,4-Dimethylazetidines Map the Binding Orientation of the Diethylamide Moiety in the Potent Hallucinogenic Agent N,N-Diethyllysergamide (LSD) Journal of Medicinal Chemistry September 1, 2002
- Stereoselective LSD-like Activity in a Series of d-Lysergic Acid Amides of (R)- and (S)-2-Aminoalkanes Journal of Medicinal Chemistry March 1, 1995
- Drug discrimination and receptor binding studies of N-isopropyl lysergamide derivatives. Pharmacology, Biochemistry, and Behavior March 1994