The synthesis of 14C‐diethylamine and lysergic acid diethylamide
R. D. Barnes
Journal of Labelled Compounds April 1, 1974 DOI: 10.1002/jlcr.2590100204 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | LSD |
| Key points | Describes a three-step synthesis of [14C1]-diethylamine from sodium [14C1]-acetate, followed by its reaction with a lysergic acid-imidazole complex to give [14C1]-lysergic acid diethylamide. |
Abstract
AbstractThe preparation of lysergic acid [14C1]‐diethylamide is described. [14C1]‐Diethylamine was synthesised in three steps; sodium [14C1]‐acetate was treated with thionyl chloride giving [14C1]‐acetyl chloride which was reacted with ethylamine to give N‐ethyl‐[14C1]‐acetamide. Reduction of this amide with lithium aluminium hydride gave [14C1]‐diethylamine which on treatment with a lysergic acid‐imidazole complex gave the required product.
Comparable studies
Other theoretical and historical papers on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The Experimental Use of Psychedelic (LSD) Psychotherapy | 1970 | Historical analysis | |
| LSD: My Problem Child | 1981 | Historical analysis | |
| On the Use and Abuse of LSD | 1968 | Theoretical or philosophical paper | |
| The Use of Music in Psychedelic (LSD) Psychotherapy | 1972 | Theoretical or philosophical paper | |
| Flashbacks: Recurrent Intrusive Images After the Use of LSD | 1969 | Theoretical or philosophical paper |