Mechanism of lysergic acid diethylamide interference with rabbit antibody biosynthesis
Edward W. Voss, Jeffrey L. Winkelhake
Proceedings of the National Academy of Sciences 1974 DOI: 10.1073/pnas.71.4.1061 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Lymphoid cells from hyperimmune rabbits |
| Intervention | d-lysergic acid diethylamide |
| Topics | LSD |
| Citations | 8 |
| Key findings | Incubation with LSD led to secretion of low-molecular-weight proteins with pI 4.9 and 5.2 instead of the typical 7S IgG with pI 7.0. |
Abstract
Lymphoid cells from hyperimmune rabbits producing antibodies to a hapten, incubated in the presence of d-lysergic acid diethylamide, continued to synthesize protein at a normal rate. Isoelectric focusing analysis of the low-molecular-weight protein secreted by the cells incubated with lysergic acid diethylamide indicated two components, with pI's of 4.9 and 5.2. Immune cells not exposed to lysergic acid diethylamide secreted only 7S IgG molecules with an average pI of approximately 7.0.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 4
- Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities Frontiers in Immunology July 14, 2015
- Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT. Scientific Reports October 9, 2017
- Using Psychedelics in Clinical Practice: Comparing Therapeutic Uses and Potential Harms. Current reviews in clinical and experimental pharmacology 2023
- Short term changes in the proteome of human cerebral organoids induced by 5-methoxy-N,N-dimethyltryptamine bioRxiv (Cold Spring Harbor Laboratory) February 13, 2017