We conducted regional cortical blood flow studies using the xenon-133 clearance technique on 12 volunteers during the administration of 25% and 50% N2O and during baseline conditions (breathing room air or 100% O2). Global cortical blood flow was very highly significantly increased above baseline measures in all subjects by 50% N2O (mean increase 37% above 100% O2 condition). A smaller but...
A 20-year-old white woman developed a left hemiplegia following the ingestion of LSD. Initial angiography revealed marked constriction of the internal carotid artery at the level of the siphon which, in a few days, was converted to occlusion of the carotid artery at that level. It is suggested that LSD, an amine derivative of the ergot alkaloids, was responsible for the initial vasoconstriction...