Drug Addiction Mechanisms in the Brain
April 8, 2024
Jayalakshmi Krishnan
LSD is a potent hallucinogen. It was first synthesised in 1938. It is marketed under numerous names. Ergot, a fungus that develops on rye and grains, is used to make LSD. The effect of LSD is mind-altering, pleasurable, and stimulating. Sometimes, exposure to this drug causes so-called unpleasant experiences, such as “bad trips”. It is classified as a Class 1 drug (highly abused) by the Drug...
European Psychiatry
April 1, 2024
P. Castro, J. Maia
IntroductionPsychedelics are substances consumed for recreational use, the majority of these psychoactive substances are illegal and hard to obtain. Therefore, there is a demand for psychedelics legal and easier to access, these types of drugs are called ‘legal highs’. LSA (lysergic acid amide) is one of these new psychoactive substances, this drug is searched because it is known to have an...
Neuropsychopharmacology
April 1, 2024
Hanna Molla, Royce Lee, Ilaria Tare et al.
37 citations
Recent studies and anecdotal reports suggest that psychedelics can improve mood states, even at low doses. However, few placebo-controlled studies have examined the acute effects of low doses of LSD in individuals with psychiatric symptoms. In the current study, we examined the acute and sub-acute effect of a low dose of LSD (26 µg) on subjective effects and mood in volunteers with mild...
ACS Pharmacology & Translational Science
March 8, 2024
Grant C. Glatfelter, Eline Pottie, John S. Partilla et al.
28 citations
Lisuride is a non-psychedelic serotonin (5-HT) 2A receptor (5-HT2A) agonist and analogue of the psychedelic lysergic acid diethylamide (LSD). Lisuride also acts as an agonist at the serotonin 1A receptor (5-HT1A), a property known to counter psychedelic effects. Here, we tested whether lisuride lacks psychedelic activity due to a dual mechanism: (1) partial agonism at 5-HT2A and (2) potent...
Scientific Reports
February 22, 2024
Ethan V Hagen, Melike Schalomon, Yanbo Zhang et al.
11 citations
The therapeutic use of lysergic acid diethylamide (LSD) has resurfaced in the last decade, prompting further scientific investigation into its effectiveness in many animal models. Zebrafish (Danio rerio) are a popular model organism in medical sciences and are used to examine the repeated administration of pharmacological compounds. Previous zebrafish research found acute LSD altered behaviour...
BMC Neuroscience
February 5, 2024
Robin J Murphy, Kate Godfrey, Alexander D Shaw et al.
16 citations
Microdosing psychedelics is a phenomenon with claimed cognitive benefits that are relatively untested clinically. Pre-clinically, psychedelics have demonstrated enhancing effects on neuroplasticity, which cannot be measured directly in humans, but may be indexed by non-invasive electroencephalography (EEG) paradigms. This study used a visual long-term potentiation (LTP) EEG paradigm to test the...
Journal of Psychedelic Studies
February 1, 2024
Jeremy Weleff, Akhil Anand, Elizabeth N. Dewey et al.
8 citations
Abstract Background Lysergic acid diethylamide (LSD) use has risen in the United States in recent years amid increased interest in therapeutic applications of psychedelics. Despite this, contemporary epidemiological investigations of LSD users are few. To expand the literature on this topic, we sought to characterize past-year LSD users in the United States and investigate recent demographic...
Revista Intertox de Toxicologia Risco Ambiental e Sociedade
January 31, 2024
Gabriela Gadelha Rattacaso, Raíssa Almeida de Moraes, Tatiana Paschoalette Rodrigues Bachur
1 citation
Drogas psicodélicas, a exemplo da dietilamida do ácido lisérgico (LSD), são substâncias psicoativas usadas em diversos contextos socioculturais e que, nas últimas décadas, têm ganhado atenção especial quanto a possibilidade de seu uso no tratamento psiquiátrico de alguns transtornos mentais. Neste contexto, o objetivo do presente estudo foi revisar a literatura científica a fim de elucidar os...
Science
January 19, 2024
Alexis Turner
A pair of anthropologists’ personal papers shed light on US psychedelic science in the mid-20th century
2024
Frank P. Petersen
Dale gefragt wurde, wer die Isolierung des wasserlöslichen, mysteriösen Wirkstoffs aus den Keulenkopf-Sklerotien angehen könne, dachte er gleich an seinen langjährigen Kollegen und Chefchemiker Harold Ward Dudley (1887–1935) am National Institute for Medical Research. Er kannte ihn bestens von gemeinsamen Forschungsarbeiten zu Histamin, Acetylcholin und Insulin, bei denen Dudley harte Nüsse zu...