Psychological Medicine
October 2, 2017
André Schmidt, Felix Müller, Claudia Lenz et al.
62 citations
Abstract Background Recent evidence shows that the serotonin 2A receptor (5-hydroxytryptamine2A receptor, 5-HT 2A R) is critically involved in the formation of visual hallucinations and cognitive impairments in lysergic acid diethylamide (LSD)-induced states and neuropsychiatric diseases. However, the interaction between 5-HT 2A R activation, cognitive impairments and visual hallucinations is...
Acta Psychiatrica Scandinavica
September 21, 2017
Felix Müller, Claudia Lenz, Patrick C. Dolder et al.
149 citations
Objective It has been proposed that the thalamocortical system is an important site of action of hallucinogenic drugs and an essential component of the neural correlates of consciousness. Hallucinogenic drugs such as LSD can be used to induce profoundly altered states of consciousness, and it is thus of interest to test the effects of these drugs on this system. Method 100 μg LSD was...
Global Journal of Health Science
September 18, 2017
Ahmed Al-Imam
BACKGROUND: Novel psychoactive substances (NPS) represent a unique phenomenon of the 21st century. These substances are of critical consequences on public health and national economies. Hallucinogens, also known as psychedelics and entheogens, represent one category of NPS. Numerous private groups do exist on the online drug fora and the online social platforms including Facebook. Psychedelic...
Psychopharmacology
September 16, 2017
Yasmin Schmid, Matthias E. Liechti
234 citations
RATIONALE: Lysergic acid diethylamide (LSD) and other serotonergic hallucinogens can induce profound alterations of consciousness and mystical-type experiences, with reportedly long-lasting effects on subjective well-being and personality. METHODS: We investigated the lasting effects of a single dose of LSD (200 μg) that was administered in a laboratory setting in 16 healthy participants. The...
Cerebral Cortex
September 12, 2017
Frederick S. Barrett, Katrin H. Preller, Marcus Herdener et al.
52 citations
Abstract Classic psychedelic drugs (serotonin 2A, or 5HT2A, receptor agonists) have notable effects on music listening. In the current report, blood oxygen level-dependent (BOLD) signal was collected during music listening in 25 healthy adults after administration of placebo, lysergic acid diethylamide (LSD), and LSD pretreated with the 5HT2A antagonist ketanserin, to investigate the role of...
American Journal on Addictions
September 2017
Shaul Lev-Ran, Daniel Feingold, Craig Goodman et al.
Exploring differences in visual disturbances and triggers between Hallucinogen-Persisting-Perceptual-Disorder (HPPD) Type I ("positive/benign") and II ("negative/distressing"). Forty individuals with HPPD and prior LSD use completed clinical questionnaires. The most common type of visual disturbances among individuals with HPPD I and II was slow movement of still objects and trailing phenomena,...
International Pharmacopsychiatry
August 11, 2017
V. Máthé, G. Kassay
Authors investigated the effect of LSD-25, of chlorpromazine, and of a combination of both on three parts of the brain of white rats (I: cortex and white substance extending to the subcortex; II: subcortical ganglia and medulla oblongata; III: cerebellum) upon the level of total reducing substance, glycogen, lactic, and pyruvic acid, ATP, and anorganic P. Twenty minutes after injecting 2ɣ per...
History of Psychiatry
July 7, 2017
Colin A. Ross
7 citations
Extensive LSD testing was conducted by the US Army at Edgewood Arsenal and other locations from 1955 to 1967. A number of different reports have been produced describing the health effects of this testing, including the Veterans Health Initiative Report in 2003. By and large, these reports gloss over and minimize the short and long-term side effects and complications of this testing. However,...
Nordic Journal of Psychiatry
July 5, 2017
Jens Knud Larsen
15 citations
Despite the significant limitations to a retrospective design, this database warrants caution in mental health patients. The use of LSD and psilocybin in mental health patients may be associated with serious short- and long-term side effects. Until further trials with rigorous designs have cleared these drugs of their potential harms, their clinical utility in these groups of patients has not...
Psychopharmacology
July 1, 2017
Rainer Kraehenmann, Dan Pokorný, Leonie Vollenweider et al.
Rationale Accumulating evidence indicates that the mixed serotonin and dopamine receptor agonist lysergic acid diethylamide (LSD) induces an altered state of consciousness that resembles dreaming. Objectives This study aimed to test the hypotheses that LSD produces dreamlike waking imagery and that this imagery depends on 5-HT2A receptor activation and is related to subjective drug effects....