Translational Psychiatry
October 6, 2026
Nadia S. Hejazi, Mina Kheirkhah, Robin Chholak et al.
Insomnia and anxiety frequently co-occur with treatment-resistant depression (TRD). This study examined short-term changes in depression, anxiety, and insomnia symptoms post-ketamine in TRD and their inter-relationships. Seventy-one patients with TRD were assessed at baseline and 24 h after intravenous ketamine (0.5 mg/kg). Depression, anxiety, and insomnia were measured using the...
Brain Research Bulletin
October 6, 2026
Ziyi Hua, Yongqiang Shu, Li Li et al.
INTRODUCTION: This study investigated changes in multiband amplitude of low-frequency fluctuations in patients with major depressive disorder following a 2-week combination treatment regimen of esketamine and sertraline, and examined the associations between ALFF changes and clinical symptom improvement. METHODS: Forty patients with major depressive disorder (MDD) received esketamine (0.25...
Psychological Medicine
October 6, 2026
Avery Chan Eun, Kevin H. Yang, Joseph J Palamar
Psilocybin use has increased in the US alongside promising therapeutic potential for depression, raising concerns that individuals may forgo conventional mental health treatment for unsupervised psilocybin use. However, no nationally representative studies have examined whether psilocybin use is associated with differential treatment utilization or perceived unmet need for mental health care...
Cogent Arts and Humanities
October 5, 2026
Khaled Al-Kassimi, Layal Hmaidi
Mainstream secular psychology is grounded in an epistemological framework that privileges reason while largely excluding revelation, thereby limiting its capacity to engage the spiritual dimensions of contemporary mental health and socio-political crises. Yet recent decades have witnessed growing scholarly and clinical interest in non-secular epistemologies that affirm the spiritual essence of...
Research Square
October 5, 2026
Anette Kjellgren, Johan Lundberg, Hampus Yngwe et al.
preprint
Abstract Psilocybin treatment has emerged as a promising intervention for Major Depressive Disorder (MDD). However, the contribution of psychotherapeutic support to treatment outcomes remains unclear. This study explored therapists' descriptions of their work during a randomized, double-blind, placebo-controlled psilocybin treatment phase II trial for MDD. Nine therapists participated in...
Pharmacopsychiatry
October 2, 2026
Masami Murao, Daiki Setoyama, Yasuyuki Matsumoto et al.
Abstract This study investigated the antisuicidal effects of repeated intravenous ketamine in patients with treatment-resistant depression and explored associations between suicidal ideation and temporal changes in selected plasma biomarkers to identify potential biomarkers. This secondary analysis of an open-label trial included outpatients with treatment-resistant depression who received four...
Health science reports
October 1, 2026
Naya Saadeh, Elie Atallah, Mirna A. Fawaz et al.
ABSTRACT Background and Aims Somatization, the physical manifestation of emotional and psychological distress, is a prevalent issue in populations exposed to war and trauma. War‐related nightmares are common among displaced individuals and are linked to depression, anxiety, and somatization. Yet, the indirect role of depression‐anxiety in the association between war‐related nightmares and...
Current Psychology
October 1, 2026
Mary-Anne Kate, Benjamin Dixon, David L. Hegarty et al.
Abstract: This study examined the relationship between depression and dissociation by assessing how specific dissociative symptoms vary with depression severity in a large Australian clinical sample. A total of 5,384 adults receiving mental health care completed the Depression Anxiety Stress Scales-21 (DASS-21) and the Multidimensional Inventory of Dissociation-60 (MID-60). Analyses included...
International Journal of Pharmaceutical and Clinical Research
October 1, 2026
H Gayathri, J Nivedhya, K Purushothama Reddy et al.
Aim: To assess the effectiveness of ketamine-based treatment for adults with treatment-resistant depression in terms of the persistence of antidepressant responses or remission after treatment discontinuation. Data Sources: PubMed/MEDLINE database search was performed to select randomized clinical trials that assessed the effect of ketamine interventions on TRD in adults. Study Selection: The...
Journal of Psychiatric Research
October 1, 2026
Erica Kaczmarek, Sabrina Wong, Noah Chisamore et al.
Background Anhedonia is a debilitating core feature of mood disorders, and is associated with significant functional impairment and poor quality of life. Psilocybin has recently emerged as a novel antidepressant treatment in MDD, however, its effects on anhedonia specifically have yet to be systematically reviewed. This review evaluates available clinical and pre-clinical research, exploring...