Ari Brouwer, Robin Carhart-Harris, Charles L. Raison
preprint
It is a paradox that psychotomimetic drugs can relieve symptoms that increase risk of and cooccur with psychosis, such as attention and motivational deficits (e.g., amphetamines), pain (e.g., cannabis) and symptoms of depression (e.g., psychedelics, dissociatives). We introduce the ideas of psychotomimetic compensation and psychotomimetic sensitization to explain this paradox. Psychotomimetic...
Vinitha Ganesan, Priyam Singh, Ritu Aneja et al.
preprint
Rhythmic breathwork rooted in yogic tradition has been associated with stress reduction, partly through modulation of autonomic balance via increased parasympathetic vagal activity. However, the integrated psycho-neuro-immune mechanisms through which these autonomic shifts translate into downstream immune and molecular changes remain incompletely characterized. We conducted a pilot randomized...
Joaquín García-alandete
preprint
Abstract Self-transcendence can be defined as what goes beyond one’s limitations and difficulties in life in order to serve or connect with something greater. Self-transcendence is related to both mental and physical health in older people, so it is important to have instruments to measure it properly. This study analyzes the psychometric properties of Wong’s Self-Transcendence Measure-Brief...
Navin Cooray, Chetan Gohil, Brendan Harris et al.
preprint
Abstract Mental health disorders affect countless people worldwide and present a major challenge for mental health services, which are struggling with the demand on a global scale. Recent studies have indicated that activity of the brain’s Default Mode Network (DMN) could prove insightful in monitoring patient recovery from depression and has been used as a therapeutic target itself. An...
Stephanie Rosemann, Josef P. Rauschecker
preprint
Tinnitus is the perception of a ringing, buzzing or hissing sound “in the ear” without external stimulation. Previous research has demonstrated changes in resting-state functional connectivity in tinnitus, but findings do not overlap and are even contradictory. Furthermore, how altered functional connectivity in tinnitus is related to cognitive abilities is currently unknown. Here we...
Halle Miller, Johanna Chajes, Tobias Grossmann
preprint
Abstract This study investigates the early neural and temperament precursors to internalizing psychopathology. Increased default mode network (DMN) functional connectivity and decreased frontoparietal network (FPN) connectivity are established neural signatures of internalizing disorders in adults, but it is unknown if these patterns represent early-emerging vulnerability. In a community sample...
B.T Dunkley, Karolina Urban, L. Da Costa et al.
preprint
Abstract Background Concussion is a common form of mild traumatic brain injury (mTBI). Despite the descriptor ‘mild’, a single injury can leave long-lasting and sustained alterations to brain function, including changes to localised activity and large-scale interregional communication. Cognitive complaints are thought to arise from such functional deficits. We investigated the impact of injury...
Charlotte Mary Crisp, Ray Norbury
preprint
Current evidence suggests late chronotype individuals have an increased risk of developing depression. However, the underlying neural mechanisms of this association are not fully understood. Forty-six healthy, right-handed individuals free of current or previous diagnosis of depression, family history of depression or sleep disorder underwent resting-state functional Magnetic Resonance Imaging...
Sho Ageno, Keiji Iramina
One of the resting state networks is the default mode network (DMN); the DMN is primarily concerned with self-perception, orientation, and memory. Although EEG-DMN has been suggested to be active in the ultra-low frequency band below 1 Hz based on fMRI studies, the characteristics of the network have not yet been elucidated. In this study, we measured EEG-DMN during the eye-closed resting...
Jan Wardęszkiewicz, Paweł Holas, Gerhard Andersson
preprint
Abstract Background Online Mindfulness-Based Cognitive Therapy (iMBCT) is a promising intervention for mental health, but its effectiveness in reducing depressive symptoms remains underexplored. While key mechanisms of change have been identified in traditional MBCT, their role in online delivery formats needs further investigation. Methods In this randomized clinical trial, 170 individuals...