Journal of Personalized Medicine
September 23, 2026
Aleksandra Metelska, Wojciech Ziemichód, Hanna Karakuła-juchnowicz
Objectives: A significant problem in the treatment of depressive disorders is the growing number of cases of so-called treatment-resistant depression (TRD). There is evidence of ketamine’s effectiveness in treating TRD, with response rates ranging from 40% to 90%. This review aimed to map available studies on peripheral biomarkers of response to ketamine and esketamine in the treatment of...
Neuropsychopharmacology
September 21, 2026
Balwinder Singh, Hossam M Ali, Alessandro Miola et al.
Disrupted excitation-inhibition (E/I) balance involving GABA and glutamate (Glu) is implicated in the pathophysiology of depression. Ketamine, an NMDA receptor antagonist with rapid antidepressant properties, may modulate this balance, yet proton magnetic resonance spectroscopy (¹H-MRS) studies report inconsistent findings regarding the direction, magnitude, and timing of neurochemical effects....
International Journal of Innovative Technologies in Social Science
September 21, 2026
Mateusz Gawin, Emilia Koziara, Mateusz Gadzina et al.
Major depressive disorder (MDD) is one of the leading causes of disability worldwide. A substantial proportion of patients fail to achieve remission through standard monoaminergic therapies, meeting the clinical criteria for treatment-resistant depression (TRD). TRD is associated with significant clinical morbidity and a profound economic burden on healthcare systems. This review evaluates the...
Expert Opinion on Therapeutic Targets
September 21, 2026
Sixtine Fleury, Katherine M. Nautiyal
INTRODUCTION: Depressive and anxiety disorders impose a substantial public health burden, yet current serotonergic therapies are limited by delayed onset, modest remission rates, and adverse side effects. Here we put forward the serotonin 1B receptor (5-HT1BR) as an important therapeutic target for mood related pathology. AREAS COVERED: We synthesize converging evidence from human and...
arXiv (Cornell University)
September 19, 2026
Muhammad Jawad Chowdhury, Sultanus Salehin, Akib Jayed Islam
preprint
Depression severity among patients with chronic or acute medical conditions is influenced by a complex interaction of baseline psychological state, demographic characteristics, clinical context, and engagement with behavioral interventions. This paper presents an interpretable machine-learning analysis of a multi-center longitudinal clinical cohort to predict Beck Depression Inventory-II...
BMC Psychology
September 19, 2026
I Jónsdottir, Anna Kristín Þorsteinsdóttir, Jóhanna Kr. Steingrímsdóttir et al.
Mindfulness-Based Cognitive Therapy (MBCT) has strong empirical support for preventing relapse in recurrent depression. This study aimed to evaluate whether adding MBCT as a follow-up intervention after an outpatient interdisciplinary rehabilitation programme benefits individuals with current moderate-to-severe depressive symptoms as well as those with minimal depressive symptoms at the start...
Journal of allied health
September 18, 2026
Kent E Irwin, Elizabeth Campione, Hannah Bargouthi et al.
Mental health conditions are prevalent among graduate health professions students and can negatively impact academic performance, well-being, and relationships. This systematic review evaluated the effectiveness of mind-body therapies (MBTs) on anxiety, burnout, depression, and stress in graduate health professions students. Five healthcare/academic databases were searched from 2008 through...
Psychiatry Research Neuroimaging
September 17, 2026
Juliana Lima Constantino, Jesca E. de Jager, Jasper O. Nuninga et al.
Antidepressant treatments, including conventional antidepressants and (es)ketamine, may reverse default mode network (DMN) resting-state functional connectivity (rsFC) alterations related to major depressive disorder (MDD). Despite these agents having distinct initial action mechanisms, both likely share downstream effects that lead to structural and functional adaptations in MDD-related neural...
Quality in Sport
September 17, 2026
Maciej Krzysztof Kisielewski, Natalia Fidut, Jakub Skrzypek et al.
Introduction and objective: Major depressive disorder (MDD) is a heterogeneous psychiatric condition characterized by affective, cognitive and somatic symptoms that considerably impair daily functioning. It is defined clinically by prolonged low mood, diminished interest or pleasure, and a range of associated disturbances, including changes in cognitive skills, appetite, and sleep patterns....
Journal of Huntington's Disease
September 17, 2026
Carsten Saft, Julia Jessen, David Kiefner et al.
Depression and suicidal ideation are common in Huntington's disease (HD). We report a 60-year-old male with HD who suffered from treatment-resistant depression with intermittent suicidal thoughts for 20 years, irritability and apathy. Despite multiple trials of antidepressants, no sustained improvement was achieved. Under nasal esketamine treatment his mood improved dramatically after three...