Health science reports
October 1, 2026
Naya Saadeh, Elie Atallah, Mirna A. Fawaz et al.
ABSTRACT Background and Aims Somatization, the physical manifestation of emotional and psychological distress, is a prevalent issue in populations exposed to war and trauma. War‐related nightmares are common among displaced individuals and are linked to depression, anxiety, and somatization. Yet, the indirect role of depression‐anxiety in the association between war‐related nightmares and...
Current Psychology
October 1, 2026
Mary-Anne Kate, Benjamin Dixon, David L. Hegarty et al.
Abstract: This study examined the relationship between depression and dissociation by assessing how specific dissociative symptoms vary with depression severity in a large Australian clinical sample. A total of 5,384 adults receiving mental health care completed the Depression Anxiety Stress Scales-21 (DASS-21) and the Multidimensional Inventory of Dissociation-60 (MID-60). Analyses included...
International Journal of Pharmaceutical and Clinical Research
October 1, 2026
H Gayathri, J Nivedhya, K Purushothama Reddy et al.
Aim: To assess the effectiveness of ketamine-based treatment for adults with treatment-resistant depression in terms of the persistence of antidepressant responses or remission after treatment discontinuation. Data Sources: PubMed/MEDLINE database search was performed to select randomized clinical trials that assessed the effect of ketamine interventions on TRD in adults. Study Selection: The...
Journal of Psychiatric Research
October 1, 2026
Erica Kaczmarek, Sabrina Wong, Noah Chisamore et al.
Background Anhedonia is a debilitating core feature of mood disorders, and is associated with significant functional impairment and poor quality of life. Psilocybin has recently emerged as a novel antidepressant treatment in MDD, however, its effects on anhedonia specifically have yet to be systematically reviewed. This review evaluates available clinical and pre-clinical research, exploring...
Psychedelics
October 1, 2026
David S. Mathai, Brian Pilecki, Hadi Zaki et al.
In 2019, the U.S. Food and Drug Administration (FDA) approved a patented formulation and delivery method of esketamine, the S-enantiomer of ketamine, for patients with treatment-resistant depression (TRD). While ketamine-based treatments share similarities with serotonin 2 A receptor-mediated “classic psychedelics” like psilocybin regarding subjective drug effects and stimulation of...
Psychedelics
October 1, 2026
Lorenzo Miller, Cordelia Kuiper Rauch, Keren Chen et al.
Background Psilocybin-assisted therapy has shown robust antidepressant effects among individuals with major depressive disorder (MDD); however, mechanisms of the treatment remain unclear. Depression has been associated with diminished feelings of connectedness to oneself, others, and the world, and psilocybin is thought to facilitate connectedness. This analysis of an open-label trial of...
Journal of Affective Disorders Reports
October 1, 2026
Kevin Byrne, Madeleine Odette, Eric L Garland et al.
ABSTRACT Background Healthcare workers experienced amplified depression and burnout during COVID-19. Both Mindfulness Based Stress Reduction (MBSR) and psilocybin have been shown to reduce depressive symptoms in this population, however the psychological mechanisms by which adding psilocybin to mindfulness training improves depression and trait mindfulness remain incompletely characterized....
Korea Exercise Rehabilitation Welfare Association
September 30, 2026
Do-Hyeok Jang, Sungh-Ho Hwang
This meta-analysis aimed to examine the effects of meditation-based interventions on psychological and physical outcomes in cancer patients. A total of 25 studies were included after a systematic literature search. Random-effects models were used to calculate pooled effect sizes (Hedges’ g), and meta-regression analyses were conducted to explore the moderating effects of the number of sessions,...
Clinical Psychology and Special Education
September 30, 2026
R. Ghorbani, N. Vahidi, Sh. Tamannaeifar et al.
Context and relevance. Emotion regulation and mindfulness are trans-diagnostic mechanisms underlying internalizing disorders such as Obsessive-Compulsive Disorder (OCD) and Major Depressive Disorder (MDD), having a significant influence on symptoms intensity and therapeutic effectiveness. Given the biological and phenomenological intersections as well as the high comorbidity between OCD and...
Preprints.org
September 29, 2026
Mouhammad Ousmane Ndiaye
preprint
A substantial proportion of patients with posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) do not respond to first-line treatment. Approximately 40% of PTSD patients do not respond to first-line psychotherapy, and 30.9% of MDD patients meet criteria for treatment-resistant depression. Yet standard polysomnography in these patients frequently shows REM sleep that appears...