Journal of Affective Disorders Reports - The Consciousness Library

Ayahuasca use and reported effects on depression and anxiety symptoms: An international cross-sectional study of 11,912 consumers

Journal of Affective Disorders Reports February 6, 2021 Jerome Sarris, Daniel Perkins, Lachlan Cribb et al. 72 citations

Background\nAyahuasca is a psychoactive Amazonian brew which has emerging data indicating that it has antidepressant and anxiolytic properties.\n\nMethods\nThis paper uses data from the Global Ayahuasca Project (GAP), which was undertaken across 2017-2020 and involved 11912 people, to examine the perceived effects of ayahuasca consumption on affective symptoms. The study focused on the...

DOI: 10.1016/j.jadr.2021.100098 Ayahuasca Anxiety Depression economics Clinical psychology +4

Evaluating the risk of psilocybin for the treatment of bipolar depression: A review of the research literature and published case studies

Journal of Affective Disorders Reports September 22, 2021 David E. Gard, Mollie Pleet, Ellen Bradley et al. 33 citations

Growing evidence suggests that psilocybin, the active ingredient in hallucinogenic mushrooms, can rapidly and durably improve symptoms of depression, leading to recent breakthrough status designation by the FDA and legalization for mental health treatment in some jurisdictions. Depression in bipolar disorder is associated with significant morbidity and has few effective treatments. However,...

DOI: 10.1016/j.jadr.2021.100240 Psilocybin Depression economics Bipolar disorder Psychiatry +5

A qualitative study of patients' experience of ketamine treatment for depression: The ‘Ketamine and me’ project

Journal of Affective Disorders Reports January 15, 2021 Chris Griffiths, Kate Walker, Isabel Reid et al. 26 citations

There has been a lack of in-depth interviews investigating patient experience of ketamine treatment for depression. We examined participants’ pathways to receiving ketamine infusion to treat their depression, and their responses to, lived experiences of, and attitudes towards ketamine treatment. Qualitative methods were used to conduct in-depth interviews with 13 patients (6 male; 7 female)...

DOI: 10.1016/j.jadr.2021.100079 Ketamine Dissociative Depression economics Clinical psychology +11

Childhood adversity severity modulates the associations between adaptive psychological changes and amygdala volumetric changes in response to behavioral interventions.

Journal of Affective Disorders Reports January 1, 2024 Diane Joss, Junjie Lu, Martin H. Teicher et al. 16 citations

Adverse Childhood Experience (ACE) has been shown to have detrimental impact on amygdala structure. Prior research found that adaptive psychological changes after Mindfulness-Based Interventions (MBI) were associated with amygdala volumetric changes. The present study aims to further investigate whether such effects also occur among ACE survivors and whether the effects are unique to MBI. A...

DOI: 10.1016/j.jadr.2023.100714 Full text Anxiety Depression Meditation Childhood maltreatment +2

Inside the journey: A qualitative study of intravenous ketamine therapy for treatment-resistant depression

Journal of Affective Disorders Reports April 28, 2025 Jason Perepelkin, Polixeni Hantjidis, Kirsten Robison et al. 3 citations

Introduction: Treatment-resistant depression (TRD) affects over 30 % of patients with depression and is associated with high morbidity and mortality. Intravenous (IV) ketamine has shown rapid and robust antidepressant effects for TRD. However, limited data exist on long-term maintenance and patient experiences, especially in North America. This study aims to explore the lived experiences of...

DOI: 10.1016/j.jadr.2025.100886 Full text Ketamine Major depressive disorder Treatment resistant depression Patient perspectives

Changes in neuroticism and values after naturalistic use of psychedelics and MDMA: a prospective survey study

Journal of Affective Disorders Reports July 1, 2026 Abigail E. Calder, Vincent J Diehl, Bernd Hinney et al.

Background Serotonergic psychedelics and MDMA may improve mental health through reductions in neuroticism and changes in personal values. While decreases in neuroticism following serotonergic psychedelics are sometimes observed, it is unclear which facets of neuroticism respond the most, and MDMA remains understudied. People also report value shifts after psychedelic experiences, but...

DOI: 10.1016/j.jadr.2026.101127 Neuroticism Survey research Personality Naturalistic observation +4

Revealing shortcomings in the assessment of psilocybin effects on OCD-related symptoms in preclinical and clinical studies: A systematic review

Journal of Affective Disorders Reports June 8, 2026 Marzieh Jalalian-Javadpour, Batool Ghorbani Yekta, Niloufar Reyhani et al.

Psilocybin is a chemical compound found in certain types of hallucinogenic mushrooms, known as magic mushrooms. Evidence has shown potential therapeutic effects of psilocybin on different neuropsychiatric disorders such as major depressive disorder (MDD), posttraumatic stress disorder (PTSD), anxiety disorders, and obsessive-compulsive disorder (OCD). Although the efficacy of psilocybin in...

DOI: 10.1016/j.jadr.2026.101098 Psilocybin Medline Disease Clinical trial +2

Beneficial effects of mindfulness-based intervention on hippocampal volumes and episodic memory for childhood adversity survivors

Journal of Affective Disorders Reports March 30, 2024 Diane Joss, Martin H. Teicher, Sara W. Lazar

Background: Adverse Childhood Experience (ACE) has detrimental impacts on neural development, especially hippocampal morphometry. Mindfulness-Based Interventions (MBI) has been shown to induce adaptive hippocampal changes especially at the subiculum. The present study aims to investigate the effects of MBI on subiculum volumes among ACE survivors, as well as the effects on episodic memory as a...

DOI: 10.1016/j.jadr.2024.100769 Full text Meditation Episodic memory Subiculum Cognition +2

Mantra meditation as adjunctive therapy in major depression: A randomized controlled trial

Journal of Affective Disorders Reports September 17, 2021 Holger C Bringmann, Aline Sulz, Philipp Ritter et al.

Objective: To investigate the efficacy of add-on mantra meditation compared to progressive muscle relaxation in major depression. Methods: This study was a two-arm, single-site, raterblinded, randomized controlled trial involving 123 inpatients at a psychiatric hospital diagnosed with major depression according to DSM-IV criteria (January 2017 to June 2020). The treatment group practiced mantra...

DOI: 10.1016/j.jadr.2021.100232 Full text Meditation Mantra Major depression Psychiatry +1

Papers