Skip to content

The effect of an integrated application‐supported mindfulness‐based cognitive therapy programme on depression among adolescents with non‐suicidal self‐injury: A randomized controlled trial

Russunan Jantarapakdee, Ratchaneekorn Upasen, Penpaktr Uthis, Jojo Yan Yan Kwok

British Journal of Clinical Psychology October 9, 2026 DOI: 10.1111/bjc.70101 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Open-label, two-arm randomized controlled trial Peer reviewed
Sample size 96
Population Adolescents with non-suicidal self-injury (NSSI) in two public secondary schools in Thailand
Duration Assessed at baseline, 2 weeks post-intervention, and 1-month follow-up
Topics Depression Meditation
Key findings Depressive symptoms decreased more in the app-supported MBCT group than in usual care over baseline, 2 weeks post-intervention, and 1-month follow-up, with a significant time-by-group interaction and lower overall depressive symptom scores in the intervention group. The authors conclude the programme effectively reduced depressive symptoms; effects on NSSI were not assessed.

Abstract

Abstract Objectives This study evaluated the effectiveness of an integrated, application‐supported mindfulness‐based cognitive therapy (MBCT) programme in reducing depressive symptoms among adolescents with non‐suicidal self‐injury (NSSI).

Methods: An open‐label, two‐arm randomized controlled trial was conducted in two public secondary schools in Thailand. The schools were randomly allocated to the intervention or usual‐care control condition, with eligible participants pair‐matched by sex and baseline depressive symptom severity ( n = 48 persons/group). The blended school‐based and application‐supported MBCT programme was evaluated at baseline, 2 weeks post‐intervention, and 1‐month follow‐up using repeated‐measures ANOVA.

Results: There was a significant time × group interaction, F (1.73, 162.17) = 62.59, p < .001, ηp 2 = .40, indicating differential changes in depressive symptoms between groups. Significant main effects of time, F (1.73, 162.17) = 203.59, p < .001, ηp 2 = .68 and group, F (1, 94) = 15.74, p < .001, ηp 2 = .14, were also observed, with lower depressive symptom scores overall in the intervention group.

Conclusions: The integrated application‐supported MBCT programme effectively reduced depressive symptoms among adolescents with NSSI. NSSI was used to define the target population and was not a treatment outcome; therefore, effects on NSSI cannot be interpreted.

Comparable studies

Other randomized controlled trials on depression, most cited first.

Study Year Design Participants
A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression Subjects with DSM-IV major depression (treatment resistant) 2006 Randomized, placebo-controlled, double-blind crossover study n = 18
Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients 2000 Randomized controlled trial n = 145
Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Cancer patients with life-threatening diagnoses and symptoms of depression and/or anxiety 2016 Randomized controlled trial n = 51
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Patients with cancer-related anxiety and depression 2016 Double-blind, placebo-controlled, crossover trial n = 29
Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients 2004 Randomized controlled trial n = 73

Citations in the library

Explore topics