Introduction Treatment-Resistant Depression (TRD) is a major clinical challenge, affecting about 30% of patients with major depressive disorder. It is associated with high morbidity and mortality, reflected in increased suicide risk, hospitalizations, and impaired quality of life. Electroconvulsive Therapy (ECT) remains the therapeutic gold standard, particularly in severe cases with psychotic...
Introduction Ketamine-assisted therapy shows rapid benefit in treatment-resistant depression, anxiety, and PTSD (Walsh et al. BJPsych Open 2022;8:e19). The Roots to Thrive Ketamine assisted Therapy (RTT-KaT) program is a unique 12-week program that combines 12 Community of Practice (group therapy) sessions and three ketamine medicine sessions (Tsang et al. Ther Adv Psychopharmacol...
Aims: Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist used for anaesthesia and analgesia, with increasing interest in its rapid antidepressant effects. This case evaluates the feasibility, tolerability and clinical response to subcutaneous ketamine in a medically frail older adult with psychotic depression, hypothesising that ketamine would rapidly improve engagement and...
Introduction Ketamine therapy for treatment-resistant depression has a well-established rapid antidepressant effect for acute symptom management. However, there is far less research on the efficacy of long-term maintenance therapy for relapse prevention. Objectives To examine the utility of long-term maintenance therapy with ketamine infusions delivered in a naturalistic treatment setting....
Journal of Computer ScienceJune 1, 2026Santiago Domingo Moquillaza Henríquez, Liliana Ruth Huamán Rondón, Nestor Marcial Alvarado Bravo et al.
Depression is a global mental health problem with various causes. Nowadays, with Artificial Intelligence, it can be predicted in order to take preventive measures, whether at a psychotherapeutic or pharmacological level. This research, based on a survey conducted, detects depression using logistic regression with a 91% fit to the ROC-AUC model, accuracy of 0.839188, precision 0.851354. In...
Introduction Treatment-resistant depression (TRD) represents a major challenge in psychiatry. Nearly one-third of patients with major depressive disorder fail to achieve remission despite adequate antidepressant therapy, and about 30% attempt suicide during their lifetime. Given this elevated risk, identifying treatments that rapidly reduce depressive symptoms and suicidality while improving...
Treatment-resistant depression (TRD), a persistent condition impacting up to 30% of patients with major depressive disorder, carries substantial personal and economic burden. There remains an unmet need for therapies that provide both rapid and durable improvements in TRD. Preliminary clinical trials indicate that GH001, a synthetic, inhalable formulation of mebufotenin, has the potential for...
Introduction TBI patients often suffer from severe, treatment-resistant depression and PTSD. Ketamine shows promise in non-TBI populations, but its efficacy in TBI patients needs exploration for efficacy and tolerability. Objectives Evaluate ketamine’s clinical effectiveness and safety (PHQ-9, GAD-7, PCL-5 scores) in post-TBI patients, comparing IM, intranasal, and oral routes. Methods Design:...
HEARTYJune 1, 2026Ita Apriliyani, Noor Yunida Triana
Depression is one of the psychological disorders experienced by many single mothers due to economic pressure, parenting responsibilities, and lack of social support. This condition has an impact on quality of life and parenting skills. Mindfulness is a mindfulness-based intervention approach that has been shown to be effective in reducing symptoms of depression through emotional regulation...
Older Black adults experience disproportionately high rates of chronic pain (CP) and depression, yet inequities in access, recognition, and culturally resonant treatment persist. Mindfulness-based cognitive therapy (MBCT) is an evidence-based group intervention for depression with emerging promise for CP. However, adaptations for older Black adults with comorbid CP-depression remain...