Anhedonia, a core symptom of depression, is often resistant to conventional treatments and significantly impacts quality of life. This secondary analysis aimed to evaluate the effects of psilocybin-assisted psychotherapy (PAP) on anhedonia severity in individuals with treatment-resistant depression (TRD). Participants (n = 30) with TRD and a primary diagnosis of Major Depressive Disorder or...
Abstract Background and aims Despite growing popularity and increasing legal access, psychedelic therapy remains financially inaccessible to many. This study was designed to test the feasibility of conducting group psilocybin therapy in low-income adults with depression in Oregon's regulated psilocybin program. Methods An open label, uncontrolled design was used. After a medical screening...
Abstract Background: Post-traumatic stress disorder (PTSD) is a common mental health condition affecting approximately 3-6% of the U.S. adult population annually, and is characterized by intrusive symptoms, avoidance, negative cognitive and mood alterations, and hyperarousal following trauma exposure. Ketamine shows promise as a treatment for PTSD in preliminary trials, though real-world...
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This thesis explores the use of ketamine in people with treatment-resistant depression. It starts by examining the concept of treatment-resistant depression, a term that is widely used but poorly defined. Importantly, this label may negatively influence patients’ expectations and sense of hope. As an alternative, more neutral framing is suggested.Survey data from individuals seeking ketamine...
Abstract The number of mindfulness-based interventions (MBIs) has proliferated in the last decade, as accessible evidence-based practices, to improve children’s mental health in school settings. However, some studies suggest that MBIs do not offer distinct advantages over other mental health promotion interventions. These inconsistent findings may be explained, at least in part, by the lack of...
BMC PsychiatryFebruary 9, 2026Song-Yuan Liu, Rong Huang, Zhuang Liu et al.
BACKGROUND: In recent years, evidence has suggested that subanesthetic doses of esketamine may have beneficial effects on perioperative anxiety and depression. Concurrently, various factors contribute to a high incidence of perioperative depression and anxiety in the breast cancer patient population. This study aimed to explore the impact of preoperative induction and intraoperative maintenance...
Objectives With growing interest in mindfulness-based interventions (MBIs) as tools for improving psychological well-being, this systematic review and meta-analysis aimed to evaluate the effectiveness of MBIs in reducing anxiety and depression among students.Method A systematic literature search was conducted across major electronic databases including PubMed, MEDLINE, Web of Science, CENTRAL,...
Background/Objectives: Esketamine-related dissociation is a transient, pharmacologically induced altered state that differs from the trait-like pathological dissociation typically observed in trauma-related conditions. While most studies have quantified these effects using the Clinician-Administered Dissociative States Scale (CADSS), patients' subjective phenomenology and meaning-making remain...
Treatment-resistant depression (TRD) remains a complex challenge, often requiring interventions beyond standard medications. This review explores factors that may predict positive response to electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS) and ketamine-based treatments to help guide clinical decision-making. A systematic review was conducted following PRISMA...
Major Depressive Disorder (MDD) is a common and debilitating condition. Current treatments fail to provide adequate relief in roughly one-third of individuals, resulting in treatment-resistant depression (TRD). Ketamine has emerged as a promising intervention for TRD, offering rapid and sustained antidepressant effects. However, benefits often require maintenance dosing, and long-term outcomes...
In 2025, 1 billion of the world population is considered to experience anxiety and depression, and 32% of college students in the U.S. experience moderate-severe anxiety and 18% have severe depression. Common interventions such as medication and CBT are effective in most cases but turn out to fail 50 percent because of its side effects. Mindfulness-based counseling (MBSR/MBCT) applies basic...
Background: Advancing age is frequently associated with balance impairment, increased fall risk, and psychological distress, which together contribute to loss of independence and reduced quality of life. Yoga, as a mind-body practice, has the potential to enhance physical stability as well as mental well-being in older adults. Therefore, the objective of this study was to evaluate the effects...
This article presents the study of an experimental methodology for the management of anxiety and depression based on Amit Goswami's quantum worldview, addressing the disorders of the mental, physical and vital levels to be worked also at the supramental level, where the creative process occurs through the attribution of new meanings to conditioned beliefs and patterns.The operational protocol...
Women diagnosed with endometriosis often experience heightened anxiety, depression, and a diminished quality of life (QoL). To address these issues, mindful breathing exercises have been introduced aimed at reducing anxiety and depression and enhancing overall QoL. This study aims to evaluate the levels and differences in anxiety, depression, and QoL among women with endometriosis before and...
Treatment-resistant depression (TRD) poses a serious challenge to psychopharmacology, as many patients do not achieve remission despite available therapies. The persistence and recurrence of the disease in the absence of response to antidepressant treatment highlight the complex and multifactorial nature of the disease, including the dysregulation of biological processes such as oxidative...
NeuropsychobiologyFebruary 5, 2026Lavanya Seth, Jitendriya Biswal, Surjeet Sahoo et al.
Severe depressive episodes with suicidal ideation present major therapeutic challenges and often require interventions beyond standard antidepressant therapy. Electroconvulsive therapy (ECT) remains a cornerstone treatment for refractory depression, while ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has emerged as a rapid-acting antidepressant with potential benefits in...
Classical psychedelics-a broad class of compounds that include psilocybin, lysergic acid diethylamide, dimethyltryptamine, and mescaline-have shown significant promise for the treatment of mental health conditions in recent clinical trials. Organizations such as the National Network of Depression Centers (NNDCs) can play a pivotal role in uniting researchers and clinicians working in this field...
Psychiatry ResearchFebruary 4, 2026Waseem Abu-Ashour, Rick Audas, John-Michael Gamble et al.
Background: Major depressive disorder (MDD) is a chronic condition with high relapse rates affecting patients and health systems. Cognitive behavioral therapy (CBT) and mindfulness-based cognitive therapy (MBCT) are strategies for relapse prevention, but their comparative long-term cost-effectiveness remains unclear. Methods: We developed a cohort-based Markov model with three health states,...
Ketamine is known to be a rapid-acting antidepressant, but there is limited evidence regarding which types of patients are best-suited to this treatment and whether adjunctive psychotherapy improves outcomes. In a sample of 224 patients who received five ketamine infusions at a private clinic, this study uses Bayesian mixed modeling to examine the effects of early life stress (measured with the...