Psychiatric disorders represent a leading cause of global disability yet current therapeutic strategies, based mainly on monoaminergic modulation, exhibit limited efficacy and high relapse rates for a significant patient population. This has catalyzed a paradigm shift toward understanding the biological underpinnings of mental illness. This review synthesises evidence from three rapidly...
Background: Advancing age is frequently associated with balance impairment, increased fall risk, and psychological distress, which together contribute to loss of independence and reduced quality of life. Yoga, as a mind-body practice, has the potential to enhance physical stability as well as mental well-being in older adults. Therefore, the objective of this study was to evaluate the effects...
Subanesthetic doses of ketamine, a noncompetitive NMDA receptor antagonist, impair prefrontal cortex (PFC) function in the rat and produce symptoms in humans similar to those observed in schizophrenia and dissociative states, including impaired performance of frontal lobe-sensitive tests. Several lines of evidence suggest that ketamine may impair PFC function in part by interacting with...