ACS Chemical Neuroscience
May 7, 2025
Hongshuang Wang, Xiaohui Wang
5 citations
This viewpoint explores the therapeutic potential of psychedelics in treating neuropsychiatric disorders, particularly through the modulation of brain entropy and the experience of ego dissolution. Psychedelics disrupt rigid neural patterns, facilitating enhanced connectivity and fostering profound emotional breakthroughs that may alleviate symptoms of disorders like depression, anxiety, PTSD,...
Imaging Neuroscience
April 16, 2025
Lorenzo Pasquini, Alexander J. Simon, Courtney L. Gallen et al.
4 citations
Abstract N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, characterized by a profound and immersive sense of physical transcendence alongside rich and vivid auditory distortions and visual imagery. Multimodal neuroimaging data paired with dynamic analysis techniques offer a valuable approach for identifying...
Behavioural Brain Research
April 12, 2025
Eamonn Eeles, Dana Pourzinal, Jalal Baland et al.
Consciousness, at its simplest, represents awareness of self in relation to the outside world. This can be divided further into the reasoning and rationality of Access consciousness (A-C) versus the experiential and 'what it's like' of Phenomenal consciousness (P-C). A-C is directly measurable, using standard tests of cognition and memory. However, owing to the subjective nature of P-C, its...
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
April 1, 2025
Brian Lord, John J B Allen, Shinzen Young et al.
4 citations
Mindfulness has gained widespread recognition for its benefits for mental health, cognitive performance, and well-being. However, the multifaceted nature of mindfulness, which encompasses elements such as attentional focus, emotional regulation, and present-moment awareness, complicates its definition and measurement. A key component that may underlie its broad benefits is equanimity-the...
medRxiv
February 7, 2025
Jakub Vohryzek, Anne Maj van der Velden, Willem Kuyken et al.
1 citation
preprint
BACKGROUND: Depression is a prevalent and debilitating affective disorder characterised by the dominance and persistence of depressive rumination. Mindfulness-based cognitive therapy (MBCT) is an effective treatment for recurrent depression developed specifically to target rumination and recurrence risk by training metacognitive awareness and adaptive attention, emotion and self-regulation...
Journal of Psychopharmacology
January 20, 2025
Joshua Liebnau, Felix Betzler, André Kerber
10 citations
Background: Recent clinical trials suggest promising antidepressant effects of psilocybin, despite methodological challenges. While various studies have investigated distinct mechanisms and proposed theoretical opinions, a comprehensive understanding of psilocybin’s neurobiological and psychological antidepressant mechanisms is lacking. Aims: Systematically review potential antidepressant...
Pharmaceuticals
January 19, 2025
Marco Bonaso, Letizia Biso, Benedetta Zucchini et al.
13 citations
Psychedelics, historically celebrated for their cultural and spiritual significance, have emerged as potential breakthrough therapeutic agents due to their profound effects on consciousness, emotional processing, mood, and neural plasticity. This review explores the mechanisms underlying psychedelics’ effects, focusing on their ability to modulate brain connectivity and neural circuit activity,...
Frontiers in Neurology
2025
Sui H Wong, Janet Wingrove
1 citation
Visual snow syndrome (VSS) is a neurological disorder characterized by intrusive visual symptoms and associated with dysregulation in brain networks, including the Salience Network, Default Mode Network, and thalamocortical circuits. This perspective paper examines the application of mindfulness-based cognitive therapy modified for visual symptoms (MBCT-vision) as an intervention for VSS....
Communications Biology
September 30, 2024
Pablo Castro, Andrea I. Luppi, Enzo Tagliazucchi et al.
21 citations
Resting-state functional magnetic resonance imaging evolves through a repertoire of functional connectivity patterns which might reflect ongoing cognition, as well as the contents of conscious awareness. We investigated whether the dynamic exploration of these states can provide robust and generalizable markers for the state of consciousness in human participants, across loss of consciousness...
Psychedelics
September 24, 2024
Xi Zhu, Chen Zhang, David J Hellerstein et al.
6 citations
Body dysmorphic disorder (BDD) is a severe psychiatric condition characterized by preoccupation with perceived flaws in one's appearance, which the individual views as defective or ugly. Psilocybin, a serotonin 2A receptor agonist with psychedelic properties, has emerged as a potential therapeutic agent for depression and other psychiatric disorders. This study aimed to identify subacute neural...