Psychological Medicine
September 1, 2022
Benjamin Wade, Joana R Loureiro, Ashish K Sahib et al.
18 citations
Ketamine is a rapidly-acting antidepressant treatment with robust response rates. Previous studies have reported that serial ketamine therapy modulates resting state functional connectivity in several large-scale networks, though it remains unknown whether variations in brain structure, function, and connectivity impact subsequent treatment success. We used a data-driven approach to determine...
bioRxiv (Cold Spring Harbor Laboratory)
August 25, 2022
Jiahe Zhang, Jovicarole Raya, Francesca Morfini et al.
4 citations
preprint
ABSTRACT Adolescents experience alarmingly high rates of major depressive disorder (MDD), however, gold-standard treatments are only effective for ~50% of youth. Accordingly, there is a critical need to develop novel interventions, particularly ones that target neural mechanisms believed to potentiate depressive symptoms. Directly addressing this gap, we developed a mindfulness-based fMRI...
Nature Reviews Neuroscience
August 15, 2022
Karola Kaefer, Federico Stella, B. McNaughton et al.
The spontaneous replay of patterns of activity related to past experiences and memories is a striking feature of brain activity, as is the coherent activation of sets of brain areas — particularly those comprising the default mode network (DMN) — during rest. We propose that these two phenomena are strongly intertwined and that their potential functions overlap. In the ‘cascaded memory systems...
Journal of Pain
August 4, 2022
Carly Hunt, Janelle E. Letzen, Samuel R Krimmel et al.
15 citations
Formal training in mindfulness-based practices promotes reduced experimental and clinical pain, which may be driven by reduced emotional pain reactivity and undergirded by alterations in the default mode network, implicated in mind-wandering and self-referential processing. Recent results published in this journal suggest that mindfulness, defined here as the day-to-day tendency to maintain a...
Journal of Psychiatric Research
August 1, 2022
Marco Marino, C. Spironelli, Dante Mantini et al.
Although alterations of the default mode network (DMN) in schizophrenia (SZ) have been largely investigated, less research has been carried out on DMN alterations in different sub-phenotypes of this disorder. The aim of this pilot study was to compare DMN features among SZ patients with and without auditory verbal hallucinations (AVH). Three groups of 17 participants each were considered:...
Human Brain Mapping
July 29, 2022
Hang Zhang, Shiyou Yang, Yang Qiao et al.
27 citations
The low-frequency (<0.1 Hz) fluctuation in sustained attention attracts enormous interest in cognitive neuroscience and clinical research since it always leads to cognitive and behavioral lapses. What is the source of the spontaneous fluctuation in sustained attention in neural activity, and how does the neural fluctuation relate to behavioral fluctuation? Here, we address these questions by...
Scientific Reports
July 18, 2022
Hadley Rahrig, David R. Vago, Matthew A. Passarelli et al.
83 citations
Abstract This meta-analysis sought to expand upon neurobiological models of mindfulness through investigation of inherent brain network connectivity outcomes, indexed via resting state functional connectivity (rsFC). We conducted a systematic review and meta-analysis of rsFC as an outcome of mindfulness training (MT) relative to control, with the hypothesis that MT would increase cross-network...
Pain
July 7, 2022
Gabriel Riegner, Grace Posey, Valeria Oliva et al.
41 citations
ABSTRACT: For millenniums, mindfulness was believed to diminish pain by reducing the influence of self-appraisals of noxious sensations. Today, mindfulness meditation is a highly popular and effective pain therapy that is believed to engage multiple, nonplacebo-related mechanisms to attenuate pain. Recent evidence suggests that mindfulness meditation-induced pain relief is associated with the...
Research Square
June 21, 2022
Paweł Krukow, Kamil Jonak
preprint
When performing cognitively demanding tasks, we all sometimes experience a momentary distractions or our stream of consciousness is intercepted by personal associations. This phenomenon is called Mind Wandering (MW) and it became a subject of neuroscientific investigations. Off-task thoughts can be analyzed during task performance, but currently MW is also understood as a dimension of...
Neuroimage
June 1, 2022
Brigitta Malagurski, P. F. Deschwanden, L. Jäncke et al.
Cross-sectional studies have consistently identified age-associated alterations in default mode network (DMN) functional connectivity (FC). Yet, research on longitudinal trajectories of FC changes of the DMN in healthy aging is less conclusive. For the present study, we used a resting state functional MRI dataset drawn from the Longitudinal Healthy Aging Brain Database Project (LHAB) collected...