Meditation Practice, Mindfulness, and Pain-Related Outcomes in Mindfulness-Based Treatment for Episodic Migraine.
Mindfulness April 1, 2023 Carly Hunt, Janelle E. Letzen, Samuel R Krimmel et al. 9 citations
A secondary analysis of a clinical trial compared a 12-week enhanced mindfulness-based stress reduction course (MBSR+) to stress management for headache in 98 migraine patients. Greater pre-treatment functional connectivity between the ventromedial prefrontal cortex and right nucleus accumbens predicted more meditation practice during MBSR+ and larger reductions in headache frequency. Participants who meditated more showed increased mindfulness and reduced helplessness related to pain, but not improvements in headache frequency, severity, or impact. Increased mindfulness mediated reductions in headache impact but not frequency. The findings suggest mesocorticolimbic system function relates to motivated behavior, and motivation-enhancing interventions might boost meditation engagement.