Contemporary Clinical Trials Communications
June 27, 2026
Jon G Dean, Alessandro Allen, Daniel Barrows et al.
Introduction: Chronic low back pain (cLBP) is a leading cause of disability worldwide and is frequently refractory to pharmacological treatment. Mindfulness meditation has been shown to reduce pain through modulation of self-referential, cognitive and affective mechanisms. However, the neural mechanisms supporting the direct and immediate modulation of movement-evoked cLBP by mindfulness...
Biological Psychiatry
2025
Gabriel Riegner, Jon G Dean, Tor D Wager et al.
Rather than a passive reflection of nociception, pain is shaped by the interplay between one's experiences, current cognitive-affective states, and expectations. The placebo response, a paradoxical yet reliable phenomenon, is postulated to reduce pain by engaging mechanisms shared with active therapies. It has been assumed that mindfulness meditation, practiced by sustaining nonjudgmental...
Neuropsychopharmacology
June 1, 2024
Lora Khatib, Jon G Dean, Valeria Oliva et al.
9 citations
Chronic low back pain (cLBP) is the most prevalent chronic pain condition. There are no treatments that haven been found to directly assuage evoked cLBP. To this extent, mindfulness-meditation is a promising pain therapy. Yet, it is unclear if meditation can be utilized to directly attenuate evoked chronic pain through endogenous opioids. A double-blind, randomized, and placebo-controlled...
bioRxiv (Cold Spring Harbor Laboratory)
August 15, 2023
Valeria Oliva, Gabriel Riegner, Jon G Dean et al.
1 citation
preprint
The authors discovered an error in the primary analysis and have withdrawn the results from this version of the investigation.
Pain
July 7, 2022
Gabriel Riegner, Grace Posey, Valeria Oliva et al.
41 citations
ABSTRACT: For millenniums, mindfulness was believed to diminish pain by reducing the influence of self-appraisals of noxious sensations. Today, mindfulness meditation is a highly popular and effective pain therapy that is believed to engage multiple, nonplacebo-related mechanisms to attenuate pain. Recent evidence suggests that mindfulness meditation-induced pain relief is associated with the...
Mindfulness
2022
Lora Khatib, Gabriel Riegner, Jon G Dean et al.
Gun violence is a significant problem in the United States of America. Gun violence produces lifelong psychological adversity, trauma, and grief. In the face of this epidemic, efficacious therapies that assuage gun violence-based trauma and negative health are lacking. The proposed, longitudinal pilot experiment examined the effects of an 8-week mindfulness-based stress reduction (MBSR) program...
Current Pain and Headache Reports
August 17, 2020
Alex Jinich-Diamant, Eric L Garland, Jennifer N Baumgartner et al.
This review examines recent (2016 onwards) neuroscientific findings on the mechanisms supporting mindfulness-associated pain relief. To date, its clear that mindfulness lowers pain by engaging brain processes that are distinct from placebo and vary across meditative training level. Due to rapid developments in the field of contemplative neuroscience, an update review on the neuroimaging studies...