Nature reviews. Neuroscience
May 23, 2025
Sharif I Kronemer, Peter A Bandettini, Javier Gonzalez-Castillo
5 citations
Consciousness is private. Although conscious beings directly access their own conscious experiences, the consciousness of others must be inferred through overt report: observable behaviours - such as overt facial expressions, vocalizations and body gestures - that suggest the level, state and content of consciousness. However, overt report is limited because it can be erroneous (for example,...
Nature reviews. Neuroscience
February 1, 2025
Clara Liao, Alisha N Dua, Cassandra Wojtasiewicz et al.
60 citations
A feature in the pathophysiology of major depressive disorder (MDD), a mood disorder, is the impairment of excitatory synapses in the prefrontal cortex. Intriguingly, different types of treatment with fairly rapid antidepressant effects (within days or a few weeks), such as ketamine, electroconvulsive therapy and non-invasive neurostimulation, seem to converge on enhancement of neural...
Nature reviews. Neuroscience
July 1, 2022
Anil K. Seth, Tim Bayne
836 citations
Recent years have seen a blossoming of theories about the biological and physical basis of consciousness. Good theories guide empirical research, allowing us to interpret data, develop new experimental techniques and expand our capacity to manipulate the phenomenon of interest. Indeed, it is only when couched in terms of a theory that empirical discoveries can ultimately deliver a satisfying...
Nature reviews. Neuroscience
July 5, 2021
Jonathan Smallwood, Boris C. Bernhardt, Robert Leech et al.
970 citations
The default mode network (DMN) is a set of widely distributed brain regions in the parietal, temporal and frontal cortex. These regions often show reductions in activity during attention-demanding tasks but increase their activity across multiple forms of complex cognition, many of which are linked to memory or abstract thought. Within the cortex, the DMN has been shown to be located in regions...
Nature reviews. Neuroscience
July 1, 2021
Johannes G. Ramaekers, Natasha L. Mason, Lilian Kloft et al.
Acute cannabis intoxication may induce neurocognitive impairment and is a possible cause of human error, injury and psychological distress. One of the major concerns raised about increasing cannabis legalization and the therapeutic use of cannabis is that it will increase cannabis-related harm. However, the impairing effect of cannabis during intoxication varies among individuals and may not...
Nature reviews. Neuroscience
January 22, 2021
Yaara Yeshurun, Mai Nguyen, Uri Hasson
701 citations
The default mode network (DMN) is classically considered an 'intrinsic' system, specializing in internally oriented cognitive processes such as daydreaming, reminiscing and future planning. In this Perspective, we suggest that the DMN is an active and dynamic 'sense-making' network that integrates incoming extrinsic information with prior intrinsic information to form rich, context-dependent...
Nature reviews. Neuroscience
April 20, 2016
Christof Koch, Marcello Massimini, Melanie Boly et al.
1,654 citations
There have been a number of advances in the search for the neural correlates of consciousness--the minimum neural mechanisms sufficient for any one specific conscious percept. In this Review, we describe recent findings showing that the anatomical neural correlates of consciousness are primarily localized to a posterior cortical hot zone that includes sensory areas, rather than to a...
Nature reviews. Neuroscience
September 2010
Franz X Vollenweider, Michael Kometer
After a pause of nearly 40 years in research into the effects of psychedelic drugs, recent advances in our understanding of the neurobiology of psychedelics, such as lysergic acid diethylamide (LSD), psilocybin and ketamine have led to renewed interest in the clinical potential of psychedelics in the treatment of various psychiatric disorders. Recent behavioural and neuroimaging data show that...
Nature reviews. Neuroscience
November 2009
J Allan Hobson
Dreaming has fascinated and mystified humankind for ages: the bizarre and evanescent qualities of dreams have invited boundless speculation about their origin, meaning and purpose. For most of the twentieth century, scientific dream theories were mainly psychological. Since the discovery of rapid eye movement (REM) sleep, the neural underpinnings of dreaming have become increasingly well...
Nature reviews. Neuroscience
September 2002
J Allan Hobson, Edward F Pace-Schott
Sleep can be addressed across the entire hierarchy of biological organization. We discuss neuronal-network and regional forebrain activity during sleep, and its consequences for consciousness and cognition. Complex interactions in thalamocortical circuits maintain the electroencephalographic oscillations of non-rapid eye movement (NREM) sleep. Functional neuroimaging affords views of the human...