Psychiatry Research Neuroimaging
October 1, 2025
Clemens C C Bauer, Jiahe Zhang, Francesca Morfini et al.
Auditory hallucinations (AHs) affect 60-80 % of schizophrenia patients and often resist antipsychotic treatment. AHs involve superior temporal gyrus (STG) hyperactivity and disrupted auditory-cognitive control connectivity. Real-time fMRI neurofeedback (NFB) enables voluntary modulation of targeted brain regions. We previously showed STG-targeted NFB with mindfulness meditation reduced STG...
Brain plasticity
May 1, 2024
Trevor L. Cline, Francesca Morfini, E. Tinney et al.
BACKGROUND: A single bout of aerobic exercise can provide acute benefits to cognition and emotion in children. Yet, little is known about how acute exercise may impact children’s underlying brain networks’ resting-state functional connectivity (rsFC). OBJECTIVE: Using a data-driven multivariate pattern analysis, we investigated the effects of a single dose of exercise on acute rsFC changes in...
BMC Psychiatry
October 17, 2023
Paul A Bloom, David Pagliaccio, Jiahe Zhang et al.
17 citations
Adolescence is characterized by a heightened vulnerability for Major Depressive Disorder (MDD) onset, and currently, treatments are only effective for roughly half of adolescents with MDD. Accordingly, novel interventions are urgently needed. This study aims to establish mindfulness-based real-time fMRI neurofeedback (mbNF) as a non-invasive approach to downregulate the default mode network...
September 23, 2023
Paul Alexander Bloom, David Pagliaccio, Jiahe Zhang et al.
preprint
Adolescence is characterized by a heightened vulnerability for Major Depressive Disorder (MDD) onset, and currently, treatments are only effective for roughly half of adolescents with MDD. Accordingly, novel interventions are urgently needed. This study aims to establish mindfulness-based real-time fMRI neurofeedback (mbNF) as a non-invasive approach to downregulate the default mode network...
Molecular Psychiatry
June 1, 2023
Jiahe Zhang, Jovicarole Raya, Francesca Morfini et al.
65 citations
Adolescents experience alarmingly high rates of major depressive disorder (MDD), however, gold-standard treatments are only effective for ~50% of youth. Accordingly, there is a critical need to develop novel interventions, particularly ones that target neural mechanisms believed to potentiate depressive symptoms. Directly addressing this gap, we developed mindfulness-based fMRI neurofeedback...
bioRxiv (Cold Spring Harbor Laboratory)
August 25, 2022
Jiahe Zhang, Jovicarole Raya, Francesca Morfini et al.
4 citations
preprint
ABSTRACT Adolescents experience alarmingly high rates of major depressive disorder (MDD), however, gold-standard treatments are only effective for ~50% of youth. Accordingly, there is a critical need to develop novel interventions, particularly ones that target neural mechanisms believed to potentiate depressive symptoms. Directly addressing this gap, we developed a mindfulness-based fMRI...