Psychopharmacology
February 7, 2025
Sabrina Zequeira, Emely A. Gazarov, Alara A. Güvenli et al.
With increasing legalization of recreational and medical cannabis, use of this drug is growing rapidly among older adults. As cannabis can impair cognition in young adults, it is critically important to understand how its consumption interacts with the cognitive profile of aged subjects, who are already at increased risk of decline. The current study was designed to determine how cannabis...
Clinical pharmacology and therapy
February 3, 2025
Andriy A Gorbenko, Jules A A C Heuberger, Maria J Juachon et al.
Emergency department visits due to cannabinoid‐induced toxicity, including acute cannabinoid intoxication (ACI) have increased worldwide as more states have liberalized cannabis policy. ACI symptoms include anxiety, panic attacks, tachycardia, and psychosis, primarily mediated through cannabinoid type 1 receptor (CB1) agonism by Δ9‐tetrahydrocannabinol (THC). This phase II randomized,...
JAMA Network Open
February 1, 2025
Daniel T. Myran, Michael Pugliese, Lyndsay D. Harrison et al.
Key Points Question Were the liberalization of medical cannabis and the legalization of nonmedical cannabis in Canada associated with changes in the population-attributable fraction of cannabis use disorders associated with schizophrenia? Findings In this population-based cohort study comprising 13 588 681 individuals, the population-attributable fraction of cannabis use disorder associated...
Cannabis and Cannabinoid Research
February 1, 2025
Margy Y. Chen, Emily B Kramer, Laurel P Gibson et al.
Objective: Cannabis has been touted for a host of pharmacological and therapeutic effects and users commonly report reduced symptoms of physical and mental health conditions, including anxiety, depression, and chronic pain. While there is existing empirical evidence supporting these effects of cannabis use, little is known about the extent to which these effects result from pharmacological...
Psychopharmacology
February 1, 2025
Maricela X. Martinez, Vanessa Alizo Vera, Christina M. Ruiz et al.
1 citation
Adolescent cannabis use is linked to later-life changes in cognition, learning, and memory. Rodent experimental studies suggest Δ9-tetrahydrocannabinol (THC) influences development of circuits underlying these processes, especially in the prefrontal cortex, which matures during adolescence. We determined how 14 daily THC injections (5 mg/kg) during adolescence persistently impacts medial...
Neuropsychopharmacology
February 1, 2025
Brian D Kangas, Harshawardhan U Deshpande, Sarah L Withey et al.
Although chronic cannabis use during adolescence can alter brain function and impair complex behavioral processes, it is unclear whether such deficits persist into adulthood. Using a coordinated awake neuroimaging and behavioral approach in nonhuman primates, we addressed this issue by examining the impact of chronic adolescent exposure to Δ9-tetrahydrocannabinol (THC) on brain functional...
Neurobiology of Disease
February 1, 2025
Peihan J Huang, Jake J Son, Yasra Arif et al.
The legalization of recreational cannabis use has expanded the availability of this psychoactive substance in the United States. Research has shown that chronic cannabis use is associated with altered working memory function, however, the brain areas and neural dynamics underlying these affects remain poorly understood. In this study, we leveraged magnetoencephalography (MEG) to investigate...
Addiction Biology
February 1, 2025
Kellen M McDonald, Mikki Schantell, Jason A John et al.
Despite its widespread use and popularity, cannabis is known to impact higher order cognitive processes such as attention and executive function. However, far less is known about the impact of chronic cannabis use on cognitive flexibility, a component of executive function, and this is especially true for the underlying functional connectivity dynamics. To address this, we enrolled 25 chronic...
The International Journal of Neuropsychopharmacology
February 1, 2025
Martine Skumlien, Tom P. Freeman, Daniel L. Hall et al.
Abstract Background Cannabis, and its main psychoactive compound tetrahydrocannabinol (THC), may alter the brain’ s reward system both acutely and over time. The endocannabinoid and reward systems mature during adolescence and adolescents may therefore respond differently to acute cannabis exposure compared with adults. Despite this, no previous functional magnetic resonance imaging (fMRI)...
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
February 1, 2025
Costanza Mazzantini, Lorenzo Curti, Daniele Lana et al.
Cannabis derivatives are among the most widely used psychoactive substances in the world, which leads to growing medical concerns regarding its chronic use and abuse especially among adolescents. Exposure to THC during formative years produces long-term behavioral alterations that share similarities with symptoms of psychiatric and neurodevelopmental disorders. In this study, we have analyzed...
Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention
January 21, 2025
Jennifer L. Schumann, Matthew Di Rago, Noel Woodford et al.
1 citation
Driving under the influence of alcohol and other drugs contributes significantly to road traffic crashes worldwide. This study explored trends of alcohol, methylamphetamine (MA), 3,4-methylenedioxy-N-methylamphetamine (MDMA) and Δ9-tetrahydrocannabinol (THC), in road crashes from 2010 to 2019 in Victoria, Australia. We conducted a cross-sectional analysis using data from the Victorian Institute...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
January 10, 2025
Xueyi Zhang, Zhengju Chen, Benjamin Becker et al.
Differences in the volumes of the hippocampus and amygdala have consistently been observed between young adults with heavy cannabis use relative to their non-using counterparts. However, it remains unclear whether the subfields of these functionally and structurally heterogenous regions exhibit similar patterns of change in young adults with long-term heavy cannabis use disorder (CUD). This...
Nature Communications
January 8, 2025
T. Thorsen, Yashraj Kulkarni, David A. Sykes et al.
Tetrahydrocannabinol (THC) is the principal psychoactive compound derived from the cannabis plant Cannabis sativa and approved for emetic conditions, appetite stimulation and sleep apnea relief. THC’s psychoactive actions are mediated primarily by the cannabinoid receptor CB1. Here, we determine the cryo-EM structure of HU210, a THC analog and widely used tool compound, bound to CB1 and its...
Psychiatry Research Neuroimaging
January 2025
Alan N. Francis, Joan A Camprodon, Francesca Filbey
To test for sex differences in the impact of cannabis use on decision-making and brain correlates, we employed cortical thickness (CT) analysis of brain regions involved in intertemporal decision-making namely bilateral orbitofrontal cortex(OFC) and insula in young adult nondependent cannabis-users(CU) and non-users(NU) and their scores on delay discounting task. Neuroimaging analyzes of...
Frontiers in adolescent medicine
2025
Kyle A Baacke, Ryan M Sullivan, Chase A Shankula et al.
Chronic cannabis use (CU) can result in subtle deficits in cognitive performance that may be linked with alterations in underlying neural functioning. However, these network alterations are not well-characterized following monitored abstinence. Here, we evaluate differences in functional brain network activity associated with CU patterns in adolescents/young adults. Functional connectomes were...
Frontiers in adolescent medicine
2025
Alexander L. Wallace, Rachel E. Baca, Gianna Andrade et al.
The endocannabinoid (eCB) system is a regulatory mechanism that helps to maintain homeostasis in the brain. Cannabis use and circulating eCB disruptions have been linked with altered memory; however, this work has largely been done in animal models with minimal investigation into these relationships by sex. We aim to investigate how circulating eCB concentrations in cannabis using young adults...
Annals of Ayurvedic Medicine
2025
Vijaendra Bhat, Sughosh Mujumdar
Bhang, Charas, Hashish, and Ganja all come from the Cannabis sativa plant, with marijuana commonly referring to its leaves and other parts. Marijuana use, especially among adolescents, can lead to withdrawal syndrome and is associated with mental health issues such as anxiety, depression, and psychosis due to high THC levels. This can manifest as euphoria, altered states of mind, and impaired...
Brain Communications
2025
Mikki Schantell, Mia C Lulli, Kellen M McDonald et al.
The main psychoactive component in cannabis-Δ9-tetrahydrocannabinol-is known to have anti-inflammatory properties and to alter gamma oscillations, pointing to its potential as a therapeutic agent for people with HIV (PWH). However, it remains unknown how cannabis use among PWH interacts with the neural circuitry underlying inhibitory processing. Herein, using a cross-sectional study design, we...
Substance Use & Misuse
2025
Sofia E Olsson, Vishaldeep K Sekhon, Cassidy R Loparco et al.
Following the United States (U.S.) Federal Agriculture Improvement Act of 2018, many retailers began selling intoxicating cannabis products, including Delta-8 tetrahydrocannabinol (THC) as "hemp," claiming that it provided a legal loophole to do so. This qualitative study assessed Delta-8 THC messaging on YouTube, the world's second-most visited website. In 2022, two researchers searched the...
International Journal of Nursing and Medical Investigation
2025
Mukesh Kushwah, Kiran Yadav
This review article examines the diverse effects of cannabis abuse on cognitive functions, including attention, perception, memory, motor skills, executive functioning, and language abilities. The primary psychoactive compound responsible for these changes is delta-9-tetrahydrocannabinol (THC), which has an immediate impact after smoking. The timing of initial cannabis use is a significant...