bioRxiv : the preprint server for biology
June 28, 2025
Jimmy Olusakin, Mahima Dewan, Atul Kashyap et al.
preprint
Cannabis use during pregnancy is increasing, often to alleviate stress and anxiety, yet the long-term effect of prenatal cannabis exposure alone or in combination with psychosocial stress on offspring neurodevelopment or maternal behaviors remains unclear. Here, we developed a translational rodent model combining prenatal Δ9-tetrahydrocannabinol (THC) exposure with chronic psychosocial stress...
The Brown University Child & Adolescent Psychopharmacology Update
June 25, 2025
Alison Knopf
Researchers looked at a common alteration in the dopamine system to investigate the mechanism possibly linking cannabis use and schizophrenia.
Medical Cannabis and Cannabinoids
June 25, 2025
Lakshmi Kumar, Tory R Spindle, C. Austin Zamarripa et al.
Introduction: Cannabis contains hundreds of chemical constituents beyond delta-9-tetrahydrocannabinol (Δ9-THC), which is thought to be the primary driver of most of its acute pharmacodynamic effects. The entourage effect theory asserts that the pharmacological and therapeutic effects of cannabis are not solely attributable to Δ9-THC but are influenced by other constituents, such as minor...
European Archives of Psychiatry and Clinical Neuroscience
June 23, 2025
Vicente Molina, Alvaro Diez, Inés Fernández-Linsenbarth et al.
Cannabis use is highly prevalent in individuals with psychosis, raising concerns about its influence on brain function. Electroencephalography (EEG) studies have identified alterations in brain activity in psychosis, including changes in spectral entropy (SE) modulation and connectivity strength (CS). However, the degree to which cannabis use contributes to these alterations remains unclear....
Journal of Psychiatric Research
June 19, 2025
Valerio Ricci, Ilenia di Muzio, Mancusi Gianluca et al.
2 citations
AIMS: This study aimed to investigate the differences in psychotic symptomatology, dissociative symptoms, alexithymia, and aberrant salience among three groups: non-cannabis users (NU), natural cannabis users (NC), and synthetic cannabinoid users (SCs). The study also explored the patterns of alexithymia and its associations with other psychopathological dimensions in these populations....
Journal of Psychopharmacology
June 18, 2025
Maria Bălăeţ, William Trender, Annalaura Lerede et al.
2 citations
Mental health implications of COVID-19 drug use patterns are still unclear. We used data-driven clustering in a large citizen science cohort recruited agnostically to an interest in drug-use to categorise people according to common patterns of drug use and analysed their mental health symptoms (GAD-7 and PHQ-9 items), from recruitment prior to COVID-19 restrictions in 2020 (N = 242,260) to...
BRILL eBooks
June 16, 2025
Bonnie Glass‐coffin, Saundra Shanti
This chapter describes the traditions, training, alterations of consciousness, healing ritual, and ethnomedical ideologies of Cannabis sativa, which is the oldest, most widely used, yet least considered plant teacher of the psychedelic renaissance. After briefly summarizing the recent literature about the deeply intertwined histories of Cannabis sativa and its intimate relationship with human...
Journal of dual diagnosis
June 16, 2025
Amar Ghelani
Abstract Objective Cannabis use contributes to negative psychosocial outcomes among youth in Early Psychosis Intervention (EPI) programs and families are crucial to recovery. This study sought to understand how youth in EPI programs perceive their families to influence their cannabis use and how cannabis affects family relationships. Methods A qualitative approach and thematic analysis were...
June 16, 2025
Anna Waldstein, Caley Cannon
Rastafari is a Pan-African spiritual, socio-political, and ecological movement that uses the Herb (Cannabis spp.) as an entheogenic agent for decolonizing consciousness to promote well-being. The movement counters the centuries of injustice and oppression perpetrated through the trans-Atlantic slave trade with a power derived from links to African livity, a core spiritual lifestyle that...
Alcoholism & Drug Abuse Weekly
June 2, 2025
Alison Knopf
In a small study, researchers observed a possible link based on magnetic resonance imaging (MRI) between elevated dopamine function, cannabis use, and schizophrenia. It is known that cannabis use is linked to psychosis, and dopamine is linked to psychosis, but whether there is a dopamine link is unclear.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
June 2025
Gianluca Lavanco, Valentina Castelli, Cesare D'Amico et al.
Mitochondria are central to cellular energy metabolism, contributing to synaptic transmission and plasticity. The mitochondrial membranes present the cannabinoid type-1 receptor (mito-CB1R), which has been functionally linked to neuronal energy supply and cognitive processing. Prenatal exposure to Δ9-tetrahydrocannabinol (pTHC) has been associated with cognitive impairments associated with...
Smart health
June 1, 2025
Honglu Li, Bin Han, Cong Shi et al.
Cannabis use has become increasingly prevalent due to evolving legal and societal attitudes, raising concerns about its influence on public safety, particularly in driving. Existing studies mostly rely on simulators or specialized equipment, which do not capture the complexities of real-world driving and pose cost and scalability issues. In this paper, we investigate the effects of cannabis on...
Journal of Cannabis Research
May 31, 2025
Michael Von Gunten, Seth Hoffman, Addison Smartt et al.
Ventral tegmental area (VTA) dopamine signaling plays a key role in reward learning and drug dependence. VTA dopamine cell activity is regulated in part by local GABA interneurons, which participate in regulating reward prediction. Previously, our lab identified a cannabinoid type 1 receptor (CB1)-dependent form of excitatory long-term depression (LTD) in VTA GABA cells. LTD was eliminated in...
Journal of Cannabis Research
May 23, 2025
Margy Y. Chen, Ashley Brooks-Russell, Angela D Bryan et al.
As cannabis products become increasingly accessible and novel modes of administration like dabbing and vaping gain popularity, understanding how these modes impact use experiences and abuse liability is crucial. Existing studies primarily utilized laboratory settings with lower-potency research-grade cannabis, failing to capture common modes among individuals who use higher-potency legal market...
Drug Testing and Analysis
May 21, 2025
Donata Favretto, Antonello Cirnelli, Roberto Pertile et al.
2 citations
A child died in the emergency room of a local hospital a few hours after ingesting a substance the color of cork and the consistency of earth. At home, a modest amount of resinous substance was found. At the hospital, the child exhibited alterations in walking, balance, and consciousness. Intubation was needed for the onset of dyspnea, so fentanyl and ketamine were administered during the...
Neuropsychopharmacology
May 2025
Janna Cousijn, Yara J Toenders, Anne Marije Kaag et al.
While Cannabis use disorder (CUD) is twice as prevalent in males, females transition more quickly from heavy use to CUD and experience more severe withdrawal. These clinically relevant sex differences contrast the lack of knowledge about the underlying brain mechanisms. This study investigated the relationship between CUD and resting-state functional brain connectivity (RSFC), assessing...
Drug and Alcohol Dependence
May 1, 2025
Spruha Joshi, Kyle M. Snyder, Christian Thurstone et al.
An increasing number of U.S. states have legalized cannabis, but the effect on adolescent and young adult psychosis-related hospitalizations remains under-studied. Using data from Denver Health between 2005–2020, we examined associations between implementation of the Ogden Memo (expanding use of medical cannabis in Colorado, October 2009) and Amendment 64 (legalizing adult-use cannabis in...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
May 1, 2025
Danial Behzad, S. Patel, R. Besa et al.
Novel methods of cannabis use are becoming popular, but the differential impact of these new methods on cognition have not been widely studied. Further, the impact of cannabis on cognition is mediated by delta-9-tetrahydrocannabinol (THC), but few studies have directly compared the pharmacokinetics of different methods. This systematic review (PROSPERO, CRD42023442731) was conducted to...
Neurotoxicology
May 1, 2025
Giulia Tomagra, Nikita Gandlevskiy, Elena Rosso et al.
3 citations
Cannabis sativa L. presents a very complex composition that includes several secondary metabolites besides the two main compounds, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Many of these minor cannabinoids are still under investigation and are arousing increasing interest for their biological effects and potential therapeutic roles. Cannabis sativa extracts, either properly purified...
Neuropsychopharmacology
May 1, 2025
Francisco Madrid-Gambin, Noemí Haro, Natasha L. Mason et al.
4 citations
Acute intoxication from Δ9-tetrahydrocannabinol (THC, the primary active ingredient of cannabis) can lead to neurocognitive impairment and interference with day-to-day operations, such as driving. Present evaluations of THC-induced impairment in legal settings rely on biological drug tests that solely establish cannabis use, rather than cannabis impairment. The current study evaluated the...