Addiction Biology
February 1, 2025
Kellen M McDonald, Mikki Schantell, Jason A John et al.
Despite its widespread use and popularity, cannabis is known to impact higher order cognitive processes such as attention and executive function. However, far less is known about the impact of chronic cannabis use on cognitive flexibility, a component of executive function, and this is especially true for the underlying functional connectivity dynamics. To address this, we enrolled 25 chronic...
Neurobiology of Disease
February 1, 2025
Peihan J Huang, Jake J Son, Yasra Arif et al.
The legalization of recreational cannabis use has expanded the availability of this psychoactive substance in the United States. Research has shown that chronic cannabis use is associated with altered working memory function, however, the brain areas and neural dynamics underlying these affects remain poorly understood. In this study, we leveraged magnetoencephalography (MEG) to investigate...
Brain Communications
2025
Mikki Schantell, Mia C Lulli, Kellen M McDonald et al.
The main psychoactive component in cannabis-Δ9-tetrahydrocannabinol-is known to have anti-inflammatory properties and to alter gamma oscillations, pointing to its potential as a therapeutic agent for people with HIV (PWH). However, it remains unknown how cannabis use among PWH interacts with the neural circuitry underlying inhibitory processing. Herein, using a cross-sectional study design, we...
Journal of psychopharmacology (Oxford, England)
May 2024
Kellen M McDonald, Mikki Schantell, Lucy K Horne et al.
Regular cannabis is known to impact higher-order cognitive processes such as attention, but far less is known regarding cognitive flexibility, a component of executive function. Moreover, whether such changes are related to aberrations in the neural oscillatory dynamics serving flexibility remains poorly understood. Quantify the neural oscillatory dynamics serving cognitive flexibility by...