Progress in Neuro-Psychopharmacology and Biological Psychiatry
January 10, 2025
Xueyi Zhang, Zhengju Chen, Benjamin Becker et al.
Differences in the volumes of the hippocampus and amygdala have consistently been observed between young adults with heavy cannabis use relative to their non-using counterparts. However, it remains unclear whether the subfields of these functionally and structurally heterogenous regions exhibit similar patterns of change in young adults with long-term heavy cannabis use disorder (CUD). This...
Addictive Behaviors
March 25, 2023
Lan Wang, Xinqi Zhou, Xinwei Song et al.
Background and aims: Fear of missing out (FOMO) promotes the desire or urge to stay continuously connected with a social reference group and updated on their activities, which may result in escalating and potentially addictive smartphone and social media use. The present study aimed to determine whether the neurobiological basis of FOMO encompasses core regions of the reward circuitry or social...
Journal of Psychiatry and Neuroscience
February 26, 2020
Weihua Zhao, Kaeli Zimmermann, Xinqi Zhou et al.
14 citations
Background: Deficient regulation of stress plays an important role in the escalation of substance use, addiction and relapse. Accumulating evidence suggests dysregulations in cognitive and reward-related processes and the underlying neural circuitry in cannabis dependence. However, despite the important regulatory role of the endocannabinoid system in the stress response, associations between...
Psychopharmacology
December 2018
M Steffens, Claudia Neumann, A-M Kasparbauer et al.
The uncompetitive N-methyl-D-aspartate (NMDA) receptor (NMDAR) antagonist ketamine has been proposed to model symptoms of psychosis. Inhibitory deficits in the schizophrenia spectrum have been reliably reported using the antisaccade task. Interestingly, although similar antisaccade deficits have been reported following ketamine in non-human primates, ketamine-induced deficits have not been...
bioRxiv (Cold Spring Harbor Laboratory)
September 29, 2018
Weihua Zhao, Kaeli Zimmermann, Xinqi Zhou et al.
1 citation
preprint
Abstract Background Deficient regulation of stress plays an important role in the escalation of substance use, addiction and relapse. Accumulating evidence suggests dysregulations in cognitive and reward-related processes and the underlying neural circuitry in cannabis dependence. However, despite the important regulatory role of the endocannabinoid system in the stress response, associations...
Human Brain Mapping
September 12, 2018
Feng Zhou, Kaeli Zimmermann, Fei Xin et al.
80 citations
The transition from voluntary to addictive behavior is characterized by a loss of regulatory control in favor of reward driven behavior. Animal models indicate that this process is neurally underpinned by a shift in ventral-dorsal striatal control of behavior; however, this shift has not been directly examined in humans. The present resting state functional magnetic resonance imaging (fMRI)...
Psychopharmacology
March 2018
Kaeli Zimmermann, Shuxia Yao, Marcel Heinz et al.
Intact cognitive and emotional functioning is vital for the long-term success of addiction treatment strategies. Accumulating evidence suggests an association between chronic marijuana use and lasting alterations in cognitive brain function. Despite initial evidence for altered emotion processing in dependent marijuana users after short abstinence periods, adaptations in the domain of emotion...
Addiction
July 26, 2012
Daniel Wagner, Benjamin Becker, Philip Koester et al.
54 citations
Abstract Aims It is still unclear if cognitive abnormalities in human 3,4‐methylenedioxymeth‐amphetamine ( MDMA ) users existed before the beginning of use or if other confounders could explain the deficits. The present study was conducted in order to assess the relationship between beginning MDMA use and subsequent cognitive performance and to overcome previous methodological shortcomings....
Benjamin Becker, Feng Zhou
preprint
Recent advances have transformed our understanding of the neural basis of emotion from localized to distributed network-level processes, with emerging evidence indicating a central role of the default mode network (DMN), particularly medial prefrontal cortex (mPFC). The mPFC exhibits a functional gradient along its dorsal-ventral axis: dorsal regions primarily engage in negative emotional...
Kaeli Zimmermann, Keith M. Kendrick, Dirk Scheele et al.
preprint
ABSTRACT Public perception of cannabis as relatively harmless, alongside claimed medical benefits, have led to moves towards its legalization. Yet, long-term consequences of cannabis dependence, and whether they differ qualitatively from other drugs, are still poorly understood. A key feature of addictive drugs is that chronic use leads to adaptations in reward processing, blunting responsivity...