Journal of Psychiatry and Neuroscience
February 26, 2020
Weihua Zhao, Kaeli Zimmermann, Xinqi Zhou et al.
14 citations
Background: Deficient regulation of stress plays an important role in the escalation of substance use, addiction and relapse. Accumulating evidence suggests dysregulations in cognitive and reward-related processes and the underlying neural circuitry in cannabis dependence. However, despite the important regulatory role of the endocannabinoid system in the stress response, associations between...
Addiction
July 26, 2012
Daniel Wagner, Benjamin Becker, Philip Koester et al.
54 citations
Abstract Aims It is still unclear if cognitive abnormalities in human 3,4‐methylenedioxymeth‐amphetamine ( MDMA ) users existed before the beginning of use or if other confounders could explain the deficits. The present study was conducted in order to assess the relationship between beginning MDMA use and subsequent cognitive performance and to overcome previous methodological shortcomings....
Benjamin Becker, Feng Zhou
preprint
Recent advances have transformed our understanding of the neural basis of emotion from localized to distributed network-level processes, with emerging evidence indicating a central role of the default mode network (DMN), particularly medial prefrontal cortex (mPFC). The mPFC exhibits a functional gradient along its dorsal-ventral axis: dorsal regions primarily engage in negative emotional...
Kaeli Zimmermann, Keith M. Kendrick, Dirk Scheele et al.
preprint
ABSTRACT Public perception of cannabis as relatively harmless, alongside claimed medical benefits, have led to moves towards its legalization. Yet, long-term consequences of cannabis dependence, and whether they differ qualitatively from other drugs, are still poorly understood. A key feature of addictive drugs is that chronic use leads to adaptations in reward processing, blunting responsivity...