Psychiatry research. Neuroimaging - The Consciousness Library

Brain iron-sensitive markers (magnetic susceptibility and R2*) predict antidepressant response to ketamine in treatment-resistant depression.

Psychiatry research. Neuroimaging August 1, 2026 Kengo Yonezawa, Shinichiro Nakajima, Shuhei Shibukawa et al.

Ketamine may alleviate treatment-resistant depression (TRD) primarily through glutamatergic modulation, with downstream dopaminergic activation. Iron plays an important role in monoaminergic metabolism, that is also implicated in the pathophysiology of TRD. Both Quantitative Susceptibility Mapping (QSM) and Effective Transverse Relaxation Rate (R2*) mapping can determine the extent of iron...

DOI: 10.1016/j.pscychresns.2026.112229 Full text Ketamine Treatment-resistant depression Amygdala Double-blind +4

Real-time fMRI neurofeedback modulates auditory cortex activity and connectivity in schizophrenia patients with auditory hallucinations: A controlled study.

Psychiatry research. Neuroimaging October 1, 2025 Clemens C C Bauer, Jiahe Zhang, Francesca Morfini et al.

Auditory hallucinations (AHs) affect 60-80 % of schizophrenia patients and often resist antipsychotic treatment. AHs involve superior temporal gyrus (STG) hyperactivity and disrupted auditory-cognitive control connectivity. Real-time fMRI neurofeedback (NFB) enables voluntary modulation of targeted brain regions. We previously showed STG-targeted NFB with mindfulness meditation reduced STG...

DOI: 10.1016/j.pscychresns.2025.112050 Full text Default mode network Mindfulness Dorsolateral prefrontal cortex Superior temporal gyrus

Altered neural reward activation predicts clinical depression improvement after a novel loving-kindness meditation: a multimodal neuroimaging study.

Psychiatry research. Neuroimaging October 1, 2025 Zhaohua Chen, Chun Cui, Xiaoxiao Sun et al.

Major depressive disorder (MDD) has become the second largest risk factor affecting human health, with a progress in its treatment especially non-pharmacological therapies. The loving-kindness meditation (LKM) has been introduced to depression but is not popular due to requirement on awareness and concentration, and its utilization in clinical MDD is absent as well as exploration on neural...

DOI: 10.1016/j.pscychresns.2025.112059 Full text FMRI Reward card-guessing task

EEG vigilance and response to oral prolonged-release ketamine in treatment-resistant depression - A double-blind randomized validation study.

Psychiatry research. Neuroimaging July 1, 2025 Anna Monn, Corinne Eicher, Annia Rüesch et al. 2 citations

Treatment-resistant depression (TRD) is associated with reduced quality of life and elevated mortality, posing a major challenge to psychiatric care. After non-response to conventional treatments, next-level interventions such as (es)ketamine are recommended, though remission rates remain variable. Identifying reliable markers of treatment response is therefore critical. Recent evidence...

DOI: 10.1016/j.pscychresns.2025.112001 Full text Treatment-resistant depression Biomarkers biomarker Biological marker Molecular marker +5

Neural regulation of pain anticipation is associated with mindful behavior change in patients with anxiety or depression: A pilot study.

Psychiatry research. Neuroimaging March 1, 2025 Michael Datko, Jacqueline Lutz, Richa Gawande et al. 1 citation

Behavior change often requires overcoming discomfort or difficult emotions. Emotional dysregulation associated with anxiety or depression may prevent behavior change initiation among people managing chronic illness. Mindfulness training may catalyze chronic disease self-management by reducing experiential avoidance of aversive experiences that act as barriers to change initiation. Using a fMRI...

DOI: 10.1016/j.pscychresns.2024.111941 Full text Anxiety Depression Meditation Mindfulness +5

Functional hyperconnectivity between corticocerebellar networks and altered decision making in young adult cannabis users: Evidence from 7T and multivariate pattern analysis.

Psychiatry research. Neuroimaging March 1, 2023 Alan N. Francis, J. Camprodon, Francesca Filbey PhD

Decision-making (DM) impairments are important predictors of cannabis initiation and continued use. In cannabis users, how decision-making abnormalities related to structural and functional connectivity in the brain are not fully understood. We employed a three-method multimodal image analysis and multivariate pattern analysis (MVPA) on high dimensional 7 tesla MRI images examining functional...

DOI: 10.1016/j.pscychresns.2023.111613

Increased insula response to interoceptive attention following mindfulness training is associated with increased body trusting among patients with depression.

Psychiatry research. Neuroimaging December 1, 2022 Michael Datko, Jacqueline Lutz, Richa Gawande et al.

Interoceptive dysfunction is often present in anxiety and depression. We investigated the effects of an 8-week intervention, Mindfulness Training for Primary Care (MTPC), on brain mechanisms of interoceptive attention among patients with anxiety and/or depression. We hypothesized that fMRI brain response to interoception in the insula, a region known for interoceptive processing, would increase...

DOI: 10.1016/j.pscychresns.2022.111559 Full text Anxiety Meditation Interoception Intervention +2

Restoration of default mode network and task positive network anti-correlation associated with mindfulness-based cognitive therapy for bipolar disorder

Psychiatry research. Neuroimaging November 1, 2021 Tina Chou, Darin D. Dougherty, Andrew A. Nierenberg et al.

Individuals with bipolar disorder (BP) show abnormalities in the default mode network (DMN), a brain network active at rest and during self-referential cognition. In healthy individuals, the DMN is anti-correlated (strongly negatively correlated) with the task positive network (TPN), a brain network that is active during attention demanding tasks. Mindfulness has been linked to changes in DMN...

DOI: 10.1016/j.pscychresns.2021.111419 Full text

Changes in the neural correlates of self-blame following mindfulness-based cognitive therapy in remitted depressed participants.

Psychiatry research. Neuroimaging July 23, 2020 K. Williams, Rebecca Elliott, S. Mckie et al.

Mindfulness-Based-Cognitive-Therapy (MBCT) reduces vulnerability for relapse into depression by helping individuals to counter tendencies to engage in maladaptive repetitive patterns of thinking and respond more compassionately to negative self-judgment. However, little is known about the neural correlates underlying these effects. To elucidate these correlates, we investigated fMRI brain...

DOI: 10.1016/j.pscychresns.2020.111152 Full text

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