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Michael Pugliese

4 papers in the library · 31 citations · publishing 2025-2026

Papers

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Changes over time in hallucinogen-related emergency department visits in Ontario, Canada.

Addiction (Abingdon, England) July 1, 2026 Daniel T. Myran, Rachael MacDonald-Spracklin, Alexander R Levesque et al.

Recent increasing interest in hallucinogens has underscored the critical gaps in our understanding of their adverse health effects and healthcare usage over time. The current study aimed to examine changes in emergency department (ED) visit rates involving hallucinogens, clinical outcomes of visits and the characteristics of individuals with ED visits involving hallucinogens. Repeated...

Hospital-based care for hallucinogens and risk of mania and bipolar disorder: A population-based cohort study.

PLoS Medicine December 1, 2025 Daniel T. Myran, Rachael MacDonald-Spracklin, Michael Pugliese et al.

Hallucinogen use for both recreational and medical purposes is rapidly increasing globally, raising concerns about potential adverse effects. This study examined the risk of incident mania or bipolar disorder (BD) diagnosis associated with having an emergency department (ED) visit or hospitalization involving hallucinogens. We used a population-based cohort study of all individuals aged 14-65...

Mortality risk among people receiving acute hospital care for hallucinogen use compared with the general population.

CMAJ March 2, 2025 Daniel T. Myran, Jennifer Xiao, Nicholas Fabiano et al. 8 citations

Background: Although clinical trials involving psychedelic-assisted psychotherapy have not observed short-term increases in the risk of death, limited data exist on mortality associated with hallucinogen use outside of controlled trial settings. We sought to determine whether people with an emergency department visit or hospital admission involving hallucinogen use were at increased risk of...

Emergency Department Visits Involving Hallucinogen Use and Risk of Schizophrenia Spectrum Disorder.

JAMA Psychiatry February 1, 2025 Daniel T. Myran, Michael Pugliese, Jennifer Xiao et al. 23 citations

Interest in and use of hallucinogens has been increasing rapidly. While a frequently raised concern is that hallucinogens may be associated with an increased risk of psychosis, there are limited data on this association. To examine whether individuals with an emergency department (ED) visit involving hallucinogen use have an increased risk of developing a schizophrenia spectrum disorder (SSD)....