Substance Use & Misuse
July 15, 2026
Parvin Ajami Bakhtiarvand, Mohammad Reza Abedi
Substance use disorders (SUDs) affect the lives of more than 35 million people worldwide, according to 2019 data from the United Nations Office on Drugs and Crime. Current evidence suggests that MBIs may mitigate the harmful psychosocial effects associated with SUDs. Although MBIs have been extensively studied for efficacy, there remains a growing need to synthesize evidence from relevant...
Substance Use & Misuse
March 28, 2026
Graeme Knibb, Ruby Ward, Paul Christiansen et al.
Background: Self-stigma refers to the internalization of negative societal beliefs and has been associated with reduced self-efficacy, self-esteem and treatment avoidance among substance users. However, little research has explored antecedents of self-stigma such as substance use motives. This may be particularly salient for psilocybin which is used both as a therapeutic agent and a...
Substance Use & Misuse
February 1, 2026
Kai-Uwe Lewandrowski, Kenneth Blum, Sergio Schmidt et al.
Since 2000, rates of suicide and opioid overdose have sharply increased. Approximately one-third of individuals with major depressive disorder (MDD) experience treatment-resistant depression (TRD), highlighting the urgent need for novel therapeutic approaches. This review synthesizes pivotal preclinical and clinical findings on low-dose ketamine's rapid antidepressant effects and examines...
Substance Use & Misuse
December 17, 2025
Markus D Moore, Andrew Moore, Saeed K Alzghari
Ibogaine is an interesting candidate that needs further study to determine its safety and potential for treating opioid dependence.
Substance Use & Misuse
June 5, 2025
Anna Wang, Ryan Athay, Nae Won et al.
2 citations
Venue intercept survey method detected signals of recreational cannabis, psilocybin, and cocaine use in the 20 US urban cities visited over a weekend. Reported prevalence differed by region. This suggests that prevention messaging should be tailored to the specific US regions.
Substance Use & Misuse
May 1, 2025
Corinne L Chandler, Mance E Buttram, Matthew S Ellis
1 citation
Data show that recreational ketamine use appears to be increasing. This study aimed to understand how ketamine fits into broader polysubstance use in individuals with opioid use disorder (OUD). Survey data were collected from a sample of treatment-seeking individuals with OUD in March 2022. Of 301 respondents, 28.6% reported lifetime ketamine use. Ketamine use was more frequently reported among...
Substance Use & Misuse
2025
Jadyn Hartwig, Jared Kendrick, Ghonwa Ahmad et al.
3 citations
Background: Amanita muscaria, commonly known as fly agaric or fly amanita, is a mushroom renowned for its distinctive appearance and psychoactive properties attributed to its compounds, ibotenic acid, and muscimol. Contemporary interest in Amanita muscaria has surged, driven by anecdotal reports of perceived psychological and medicinal benefits. Objectives: However, no clinical studies exist...
Substance Use & Misuse
2025
Torbjørn Lien Kjær, Peter Hindersson, Jacob Rong Bentzen et al.
2 citations
Drug use in Danish prisons has previously not been investigated in detail using confirmatory, laboratory analysis. The objective of the present quality study, initiated by the Danish Prison and Probation Service, was to i) evaluate the performance of an initial, on-site drug screening strategy; ii) gain insights into emerging drug trends; and iii) suggest evidence-based strategies for future...
Substance Use & Misuse
2025
Sofia E Olsson, Vishaldeep K Sekhon, Cassidy R Loparco et al.
Following the United States (U.S.) Federal Agriculture Improvement Act of 2018, many retailers began selling intoxicating cannabis products, including Delta-8 tetrahydrocannabinol (THC) as "hemp," claiming that it provided a legal loophole to do so. This qualitative study assessed Delta-8 THC messaging on YouTube, the world's second-most visited website. In 2022, two researchers searched the...
Substance Use & Misuse
2024
Benjamin A. Korman
4 citations
Although studies have demonstrated that the use of lysergic acid diethylamide (LSD) is on the rise in the United States, it remains unclear how this trend looks across the hierarchical ladder of the American workforce. This is relevant given that LSD is increasingly being touted as a means of boosting creativity and performance, with mounting anecdotal evidence that business managers in...
Substance Use & Misuse
2023
Bahram Armoon, Mark D Griffiths, Rasool Mohammadi
13 citations
Background: Globally, street-involved children and youth (SICY) who work and live on/of the streets are at higher risk of increased psychoactive substances and injecting drug use. Objectives: The present study aimed to identify the prevalence, distribution, sociodemographic factors, and risk-taking behaviors associated with psychoactive substances and injecting drug use among SICY. Methods:...
Substance Use & Misuse
April 25, 2022
Dimitri Daldegan-Bueno, Dóra Révész, Paulo Rogério Morais et al.
15 citations
Background: Preliminary evidence suggests that long-term ayahuasca use is associated with better psychosocial outcomes and less drug use; however, available data on the association between ayahuasca intake frequency and psychosocial outcomes is limited. Objectives: We sought to characterize and investigate the association of regular ayahuasca use, as compared to non-regular use, on licit...
Substance Use & Misuse
August 17, 2021
Pravesh Sharma, Kira E. Riehm, Andrea S. Young et al.
3 citations
Background: Adolescent cannabis use is an established risk factor for the development of psychosis, but the premorbid vulnerability factors and specificity versus generality of the psychotic symptom domains affected in cannabis-psychosis relationships remain incompletely understood. To improve our understanding of these relationships, we used longitudinal data to examine the individual and...
Substance Use & Misuse
October 24, 2020
Balthazar Bazin, David Duroy, Michel Lejoyeux
27 citations
3,4-Methylenedioxy-N-methylamphetamine (MDMA) is increasing being used by youth in Europe and in France, but characteristics of its use are unknown. Objectives: The aim was to characterize MDMA use in a sample of French medical students. Methods: Cross-sectional study of Paris VII medical students (N = 592) with an online self-reporting questionnaire. Results: 592 students completed the online...
Substance Use & Misuse
2019
Thomas Lyons, Veronica Y Womack, Wm Dustin Cantrell et al.
More than half of prisoners in the United States are estimated to suffer from a substance use disorder. Mindfulness involves attention to the present moment, and nonjudgmental acceptance of sensations, thoughts, and emotional states. Mindfulness-based relapse prevention (MBRP) following substance use disorder treatment has been shown to reduce substance use. We sought to adapt and test MBRP for...
Substance Use & Misuse
June 7, 2018
Jacob Fox, Alexis Smith, Alexander Yale et al.
Drugs of abuse (DOA) are widely used in the United States and are ubiquitous at outdoor music festivals. Attendees at music festivals are at high-risk for novel psychoactive substance (NPS) use, which is becoming more prevalent worldwide. No U.S. studies have employed an qualitative approach to investigate the etiologies of both traditional DOA and NPS use amongst music festival attendees. The...
Substance Use & Misuse
January 28, 2017
Mark Haden, John R H Archer, Paul I Dargan et al.
MDMB-CHMICA (methyl 2-[[1-(cyclohexylmethyl)indole-3-carbonyl]amino]-3,3-dimethylbutanoate) is a synthetic cannabinoid receptor agonist that has been detected in several recreational drug products in Europe since August 2014. This article aims to describe the prevalence of use, availability, and desired and adverse effects of MDMB-CHMICA. Data were collated from published scientific literature,...
Substance Use & Misuse
March 11, 2014
Sam Himelstein, Stephen Saul, Albert Garcia‐romeu et al.
28 citations
Mindfulness-based treatment for adolescents is a clinical and research field still in its infancy. Literature is needed to address specific subcultural populations to expand this growing field. Further, minimal literature addresses the process of teaching mindfulness to adolescents. The current study investigated how to effectively teach mindfulness to 10 incarcerated adolescent substance users...
Substance Use & Misuse
July 2, 2013
David Michael Wood, Paul Ivor Dargan
14 citations
Alpha-methyltryptamine (AMT) is a novel psychoactive substance available over the Internet. This study used European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) Internet snapshot methodology to investigate the availability and cost of AMT in March/October 2012. From March to October 2012, there was a decrease in the number of Internet sites selling AMT (44 to 31). AMT powder was...
Substance Use & Misuse
November 1, 2010
Paolo Nencini, Kathleen A Grant
The recent interest in the psychopharmacological underpinnings of religious experiences has led to both the laboratory characterizations of drug-induced mystical events and psychobiological models of religious experiences rooted in evolution and fitness. Our examination of this literature suggests that these theories may be congruent only within more modern religious and cultural settings and...
Substance Use & Misuse
March 1, 2010
Ornella Corazza, Fabrizio Schifano
43 citations
Increase in recreational ketamine use may be a cause for concern. We aimed here at assessing, in a sample of ketamine misusers, concordance between the typical near-death experience (NDE) features and the on-drug psychoactive effects the subjects experienced. In 2003-2005, a sample of previous ketamine misusers recollecting a ketamine-related NDE were recruited through snowballing and screened...
Substance Use & Misuse
2009
Catherine Reynaud-Maurupt, Agnès Cadet‐Taïrou, Anne Zöll
8 citations
This qualitative research implemented in France between 2004 and 2007 is based on 30 in-depth interviews carried out with individuals who consumed hallucinogenic plants or mushrooms at least six times during the year preceding the interview. The interviews were recorded, retranscribed, and an analysis of their content applied for the textual data. The study focuses on drug users and the...
Substance Use & Misuse
2008
Sarah Riley, Graham Blackman
36 citations
A survey of magic mushroom use was completed by 174 participants in 2004, a year when the sale of hallucinogenic mushrooms was not illegal in the UK. The data were collected in Edinburgh and Bristol (UK). Participants were a self-selecting convenience sample. Participants tended to be in their 20s, White-British, in education or employed; 64% were male. Participants reported a pattern of...
Substance Use & Misuse
2005
Tom F. M. Ter Bogt, Rutger C. M. E. Engels
144 citations
This study examines motives for and consequences of MDMA use at different types of dance parties in the Netherlands (2001 and 2002). Participants were 490 visitors of three different types of rave parties, "club/mellow," "trance/mainstream," and "hardcore" (34% female, mean age 22.3 years, 76.5% MDMA users). Partygoers are motivated primarily by the energetic and euphoric effects they expect...
Substance Use & Misuse
2005
Karen Mcelrath
102 citations
This study examines the relationship between MDMA (Ecstasy), sexual behavior, and sexual risk taking. The sample consisted of 98 current and former users of MDMA. Several strategies were utilized to recruit respondents and data were collected through in-depth interviews during 1997 and 1998. The majority of respondents had used MDMA during the 6-month period prior to the interview and a large...