Introduction: Increased cannabis use in young adults may influence brain health and neurodevelopment. In the context of chronic HIV-associated neuroinflammation, however, mild cannabis use may attenuate negative outcomes through anti-inflammatory effects. More frequent cannabis use may remain deleterious to both young adults with HIV (YWH) and without HIV (YWoH). We explored cross-sectional...
The endocannabinoid (eCB) system is a regulatory mechanism that helps to maintain homeostasis in the brain. Cannabis use and circulating eCB disruptions have been linked with altered memory; however, this work has largely been done in animal models with minimal investigation into these relationships by sex. We aim to investigate how circulating eCB concentrations in cannabis using young adults...
Chronic cannabis use (CU) can result in subtle deficits in cognitive performance that may be linked with alterations in underlying neural functioning. However, these network alterations are not well-characterized following monitored abstinence. Here, we evaluate differences in functional brain network activity associated with CU patterns in adolescents/young adults. Functional connectomes were...
Cannabis and its main psychoactive constituent, delta-9-tetrahydrocannabinol (THC), are thought to weaken neurocognitive processes. However, past experimental research examining the acute effects of THC on neurocognition has produced mixed results. The current study aims to advance this literature through application of computational modeling and consideration of individual differences in...