Cannabinoid administration during adolescence affects various physiological processes, such as motor and affective response, cognitive-related functions and modulates neurotransmitter activity. Literature remains scant concerning the parallel examination of the effects of adolescent escalating low-dose Δ9 -tetrahydrocannabinol (Δ9 -THC) on the behavioral and plasticity profile of adult rats in...
Our results suggest that the Amazonian medicine-based therapy attracts a diverse patient group not limited to regional residents and may be particularly appealing to more impaired SUD patients with a history of unsuccessful treatment. The sample's cultural diversity suggests an existing interest in such therapies among international SUD treatment-seeking patients. These findings are relevant in...
Approximately one-third of patients presenting with a first episode of psychosis have a history of cannabis use. Some of these patients meet the criteria for cannabis-induced psychotic disorder (CIPD), which is regarded as a disorder with better outcomes compared to other psychotic disorders. The aim of this paper was to determine whether there are differences in clinical and demographic...
The past decade has seen a reduction in society’s perception of cannabis being of any risk or harm. However, we are in a transformational time in which cannabis’ health implications related to neurodevelopment, particularly for vulnerable populations, must challenge such perceptions of harmlessness. The combination of multiple interrelated factors — societal, political, and business — have...
A 17-year-old male is brought to the emergency room by a friend who finds him strange lately. The patient is very anxious and seems to be scared. He reports having recently discovered that government was spying on him, using a complex network of cameras and satellites. He has unplugged all of his house hold electronic devices and refuses to talk to his friend on the phone. During the interview,...
Nicotine is the specific psychoactive substance of tobacco while tetrahydrocannabinol (THC) is the specific component of cannabis. The inhalation technique of cannabis is different from that of tobacco smoking: the volume of puffs is larger, inhalation is deeper, and pulmonary retention time is longer. Cannabis addiction is difficult to evaluate, both products often being smoked concomitantly....
May 27, 2020Christopher Missak, Jenie George, I. Gurubhagavatula
Marijuana use is increasing the United States and has been associated with increased sensory perception, euphoria, and altered cognition. Exploding head syndrome is a parasomnia characterized by loud explosion-like noises occurring prior to or during sleep. This the first report to link marijuana use with the occurrence of EHS. A 45-year-old man with depression, anxiety and multisubstance abuse...
Abstract Background Recent studies indicate that adolescent cannabis use (1) and cigarette smoking (2) increase the risk for psychosis. However, less is known about symptom profile associated with cannabis use and cigarette smoking prior to the psychotic episodes. Our aim was to study the associations between daily smoking, life-time cannabis use, and psychotic experiences in adolescence, and...
Abstract Background Although growing research has observed a positive association between cannabis consumption and cognition in patients with first-episode psychosis (FEP), such better performance has not always been found across all cognitive domains. Furthermore, it remains unclear whether frequency of use is related to cognitive functioning in a dose-dependent manner. Understanding these...
Research evidence suggests a dose-response relationship for the association between cannabis use and risk of psychosis. Such relationship seems to reflect not only an increased risk of psychosis as a function of frequent cannabis use, but also of high-potency cannabis use in terms of concentration of delta-9-tetrahydrocannabinol (∆9-THC), its main psychoactive component. This finding would be...
Cannabis use can increase severity of symptoms and risk of relapse for people with psychosis. Childhood sexual abuse and high schizotypy increase the risk further. The mechanisms involved remain unclear, and this limits psychological therapies. In three linked studies, we examined the role of two candidate mechanisms – external attribution and cognitive fusion. Study 1 examined these processes...
Epidemiological and biological evidence support the association between heavy cannabis use and psychosis. However, it is unclear which cannabis users are susceptible to its psychotogenic effect. Therefore, understanding genetic factors contributing to this relationship might prove an important strategy to identify the mechanisms underlying cannabis-associated psychotic experiences. We aimed to...
medRxivApril 29, 2020T. Jordan Walter, Nina Pocuca, Jared W Young et al.1 citation
preprint
ABSTRACT Bipolar disorder (BD) and cannabis use are highly comorbid and are each associated with cognitive impairment. It is therefore important to understand the relationship between cannabis use and cognition in people with BD, as cannabis use in BD may be associated with greater cognitive impairment. We performed a scoping review to determine how much and what is currently known in this...
BACKGROUND: Acute cannabis administration can produce transient psychotic-like effects in healthy individuals. However, the mechanisms through which this occurs and which factors predict vulnerability remain unclear. We investigate whether cannabis inhalation leads to psychotic-like symptoms and speech illusion; and whether cannabidiol (CBD) blunts such effects (study 1) and adolescence...
AbstractThe associative striatum, an established substrate in psychosis, receives widespread glutamatergic projections. We sought to see if glutamatergic indices are altered between early psychosis patients with and without a history of cannabis use and characterise the relationship to grey matter. 92 participants were scanned: Early Psychosis with a history of cannabis use (EPC = 29); Early...
Abstract Objectives: Previous research suggests recovery from cannabis-related deficits in verbal learning and memory functioning after periods of cannabis abstinence in adolescents. Here, we examine how cannabis cessation affects cognitive performance over 2 weeks of monitored abstinence compared to controls in adolescents and young adults. Methods: Seventy-four participants (35 cannabis...
Purpose of review This review summarizes (1) recent trends in delta-9-tetrahydrocannabionol [THC] and cannabidiol (CBD) content in cannabis products, (2) mechanism of action of THC and CBD and the neurobiological correlates of cannabis use on the developing adolescent brain, (3) effects of cannabis on psychiatric symptoms and daily functioning in youth (i.e., academic performance, cognition,...
There is a worldwide trend toward liberalizing cannabis policy and commercializing its sale. Uruguay legalized recreational cannabis in 2013, as did Canada in 2018, as well as 10 US states.1 Other countries have decriminalized the drug. In Holland, cannabis can be bought in designated cafes, and in Portugal, the police refer those who regularly use cannabis for counseling. Psychiatrists have...
Schizophrenia (SCZ) has been associated with serotonergic and endocannabinoid systems dysregulation, but difficulty in obtaining in vivo neurological tissue has limited its exploration. We investigated CB1R-5-HT2AR heteromer expression and functionality via intracellular pERK and cAMP quantification in olfactory neuroepithelium (ON) cells of SCZ patients non-cannabis users (SCZ/nc), and...
Cannabis can induce acute psychotic symptoms in healthy individuals and exacerbate pre-existing psychotic symptoms in patients with schizophrenia. Inappropriate salience allocation is hypothesised to be central to the association between dopamine dysregulation and psychotic symptoms. This study examined whether cannabis use is associated with self-reported salience dysfunction and schizotypal...