Current Treatment Options in Psychiatry
May 14, 2026
Deidre A. Marsh, Edwin Bacalso
Abstract Psychedelic-assisted therapy (PAT) is a novel and promising form of treatment for posttraumatic stress disorder (PTSD). However, clinicians may experience challenges in interpreting the existing evidence for PAT to make informed decisions about treatment recommendations and selection with their patients. Prior commentators have noted the hype surrounding public discussions of PAT. This...
Current Treatment Options in Psychiatry
December 26, 2025
Manasicha P. Wongpaiboon, Jackson L. Shelton, Eric Delgado Rendon et al.
Purpose A systematic review was conducted to synthesize the efficacy, safety, and tolerability of psychedelics including ketamine, MDMA, ayahuasca, LSD, DMT, ibogaine, and psilocybin in the treatment of PTSD. Recent Findings Among 5,155 studies identified, 42 studies met criteria and were included in our systematic review. Ketamine consistently produced rapid symptom improvement that attenuated...
Current Treatment Options in Psychiatry
November 11, 2025
Dan Petrovitch, Sarah E. Victor, André Schmidt et al.
2 citations
Abstract Purpose of Review This commentary summarizes how the intense and distinctive subjective effects of psychedelics complicate tests of the efficacy and mechanisms of action (MOAs) of psychedelic-assisted treatments (PATs) for mental-health conditions. Specifically, we discuss (a) how estimates of PAT efficacy are confounded under functional unblinding and (b) uncertainty surrounding...
Current Treatment Options in Psychiatry
July 30, 2025
Arushi Badola, Weihua Yu, Anthony P. King
3 citations
Abstract Purpose of Review Lifetime exposure to trauma is extremely common, affecting ~ 70% of global population, whereas lifetime prevalence of PTSD is ~ 6%. FDA-approved medications for PTSD have small-medium effect sizes. Trauma-focused psychotherapies are considered first-line treatments and have large effect sizes, but also high rates of dropout and refusal, and most patients retain PTSD...
Current Treatment Options in Psychiatry
May 5, 2025
Ana Malta Gomes, Filipa Novais
3 citations
Abstract Purpose of the review Treatment-resistant depression (TRD) is a challenging condition characterized by minimal improvement despite two or more antidepressant trials. Ketamine-assisted psychotherapy (KAP) integrates the rapid antidepressant effects of ketamine with psychotherapy to enhance and sustain therapeutic outcomes. This systematic review evaluates the effectiveness of KAP in...