bioRxiv : the preprint server for biology
March 6, 2026
Natasha E Wade, Ryan M Sullivan, Alexander L. Wallace et al.
preprint
Adolescents experience extensive neurocognitive development, with cannabis use potentially impacting developmental trajectories. Here, we comprehensively assess the influence of adolescent cannabis use onset on neurocognitive trajectories and consider how recent delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) may influence neurocognition. We use the large, diverse longitudinal...
Frontiers in adolescent medicine
2025
Kyle A Baacke, Ryan M Sullivan, Chase A Shankula et al.
Chronic cannabis use (CU) can result in subtle deficits in cognitive performance that may be linked with alterations in underlying neural functioning. However, these network alterations are not well-characterized following monitored abstinence. Here, we evaluate differences in functional brain network activity associated with CU patterns in adolescents/young adults. Functional connectomes were...
Frontiers in Human Neuroscience
2023
Julia C. Harris, Michael T Liuzzi, Carlos Cardenas-Iniguez et al.
Aspects of the built environment relate to health factors and equity in living conditions, and may contribute to racial, ethnic, or economic health disparities. For example, urbanicity is linked with negative factors including exposure to gray space (e.g., impervious surfaces such as concrete, streets, or rooftops). While there is existing research on access to green space and urbanicity on...
Brain Sciences
February 24, 2022
Julia C. Harris, Alexander L. Wallace, Alicia M. Thomas et al.
Background. Numerous neuropsychological studies have shown that cannabis use during adolescence and young adulthood led to deficits in sustained and selective attention. However, few studies have examined functional connectivity in attentional networks among young cannabis users, nor have characterized relationships with cannabis use patterns following abstinence. Methods. Differences in...
Journal of the International Neuropsychological Society
July 1, 2021
Krista M. Lisdahl, F. Filbey, Staci A Gruber
Given the different goals of recreational cannabis users and medical patients, which drive cannabis product choice and use patterns, it is likely that those who use cannabis for medical purposes may experience differential effects on cognition. Potential moderators of cannabis-related effects One explanation for inconsistencies in the literature regarding neurocognitive effects of cannabis is...
NeuroImage: Clinical
April 8, 2021
Megan M. Ritchay, A. Huggins, Alexander L. Wallace et al.
Highlights • We examined resting state connectivity in the DMN in cannabis users and controls.• Cannabis users displayed abnormal connectivity compared to healthy controls.• Abnormal connectivity in cannabis users related to poorer cognitive performance.• Abnormal brain communication may remain after ≥ 3 weeks of cannabis abstinence.
Journal of the International Neuropsychological Society
April 20, 2020
Alexander L. Wallace, Natasha E Wade, Krista M. Lisdahl
Abstract Objectives: Previous research suggests recovery from cannabis-related deficits in verbal learning and memory functioning after periods of cannabis abstinence in adolescents. Here, we examine how cannabis cessation affects cognitive performance over 2 weeks of monitored abstinence compared to controls in adolescents and young adults. Methods: Seventy-four participants (35 cannabis...
Archives of Clinical Neuropsychology
September 22, 2018
Alexander L. Wallace, Natasha E Wade, Kelah Hatcher et al.
43 citations
OBJECTIVE: Research has demonstrated comorbidity between Attention-Deficit Hyperactivity Disorder (ADHD) and cannabis use, and some have proposed that subclinical ADHD symptoms may explain attentional deficits in cannabis users. Here we investigated whether subclinical ADHD symptoms and cannabis use independently or interactively predict performance on attention tasks in adolescents and young...
Developmental Cognitive Neuroscience
December 2015
Skyler G Shollenbarger, Jenessa Price, Jon Wieser et al.
Regions undergoing maturation with CB1 receptors may be at increased risk for cannabis-induced alterations. Here, we examine the relationships between cannabis use and prefrontal (PFC) and inferior parietal gyrification and surface area (SA) in youth. Participants included 33 cannabis users and 35 controls (ages 18-25). Exclusions included co-morbid psychiatric/neurologic disorders and heavy...