European Neuropsychopharmacology
April 5, 2020
Valentina Lorenzetti, Eva Hoch, W. Hall
We review the findings of systematic reviews and meta-analyses of case-control studies that examine brain functioning and cognitive correlates of adolescent cannabis use using structural and functional neuroimaging tools and standardised neuropsychological tests. We also examine prospective epidemiological studies on the possible effects of adolescent and young adult cannabis use on cognitive...
Psychological Medicine
March 18, 2020
Diego Quattrone, Laura Ferraro, Giada Tripoli et al.
89 citations
Abstract Background Daily use of high-potency cannabis has been reported to carry a high risk for developing a psychotic disorder. However, the evidence is mixed on whether any pattern of cannabis use is associated with a particular symptomatology in first-episode psychosis (FEP) patients. Method We analysed data from 901 FEP patients and 1235 controls recruited across six countries, as part of...
Brain Sciences
February 27, 2020
Marco Colizzi, Sarah Tosato, Mirella Ruggeri
Several studies have advanced the understanding of the effects of cannabis on cognitive function. A comprehensive reappraisal of such literature may help in drawing conclusions about the potential risks associated with cannabis use. In summary, the evidence suggests that earlier age of use, high-frequency and high-potency cannabis use, as well as sustained use over time and use of synthetic...
Journal of Psychiatry and Neuroscience
February 26, 2020
Weihua Zhao, Kaeli Zimmermann, Xinqi Zhou et al.
14 citations
Background: Deficient regulation of stress plays an important role in the escalation of substance use, addiction and relapse. Accumulating evidence suggests dysregulations in cognitive and reward-related processes and the underlying neural circuitry in cannabis dependence. However, despite the important regulatory role of the endocannabinoid system in the stress response, associations between...
Ageing Research Reviews
February 25, 2020
G. Weinstein, Sharon R. Sznitman
While medical and recreational cannabis use is becoming more frequent among older adults, the neurocognitive consequences of cannabis use in this age group are unclear. The aim of this literature review was to synthesize and evaluate the current knowledge on the association of cannabis use during older-adulthood with cognitive function and brain aging. We reviewed the literature from old animal...
Proceedings of the National Academy of Sciences
February 10, 2020
Lilian Kloft, Henry Otgaar, Arjan Blokland et al.
49 citations
With the growing global acceptance of cannabis and its widespread use by eyewitnesses and suspects in legal cases, understanding the popular drug's ramifications for memory is a pressing need. In a double-blind, randomized, placebo-controlled trial, we examined the acute and delayed effects of Δ9-tetrahydrocannabinol (THC) intoxication on susceptibility to false memory in 64 healthy volunteers....
Adicciones
February 6, 2020
Cecilia María Díaz-Soto, Guillermo Alonso Castaño Pérez, David Antonio Pineda-Salazar
7 citations
The lack of consensus on the issue of whether the consumption of cannabis favors neurocognition among schizophrenia-diagnosed patients or not, plus methodological problems found in available evidence and the limitations of studies focused on diagnosis and treatment for positive symptoms are sufficient reason for designing new research proposals based on recent brain connectivity models. The...
Journal of Emergency Medicine
February 2020
Nathan A Finch, Gary M Vilke
Marijuana is a commonly used substance in the United States for both recreational and medicinal purposes. Detrimental health-related effects of marijuana continue to be a source of controversy. We describe a case of a woman who presented to the emergency department with acute right upper and lower extremity weakness and altered speech after accidental unknown ingestion of food containing...
Brain Science
February 1, 2020
Sanne J. van der Steur, Albert Batalla, Matthijs G. Bossong
Increasing evidence indicates a relationship between cannabis use and psychosis risk. Specific factors, such as determinants of cannabis use or the genetic profile of cannabis users, appear to moderate this association. The present systematic review presents a detailed and up-to-date literature overview on factors that influence the relationship between cannabis use and psychosis risk. A...
Neuropsychopharmacology
January 26, 2020
Adán de Salas-Quiroga, Daniel García-Rincón, Daniel Gómez-Domínguez et al.
84 citations
Abstract Prenatal exposure to Δ9-tetrahydrocannabinol (THC), the most prominent active constituent of cannabis, alters neurodevelopmental plasticity with a long-term functional impact on adult offspring. Specifically, THC affects the development of pyramidal neurons and GABAergic interneurons via cannabinoid CB1 receptors (CB1R). However, the particular contribution of these two neuronal...
Frontiers in Psychiatry
January 22, 2020
Earth Erowid, Fire Erowid, Albert Garcia‐romeu et al.
155 citations
While these cross-sectional and self-report methods cannot determine whether psychedelics caused changes in drug use, results suggest the potential that psychedelics cause reductions in problematic substance use, and support additional clinical research on psychedelic-assisted treatment for SUD.
BMC Psychiatry
January 16, 2020
Jerome Sarris, Justin Sinclair, Diana Karamacoska et al.
247 citations
BACKGROUND: Medicinal cannabis has received increased research attention over recent years due to loosening global regulatory changes. Medicinal cannabis has been reported to have potential efficacy in reducing pain, muscle spasticity, chemotherapy-induced nausea and vomiting, and intractable childhood epilepsy. Yet its potential application in the field of psychiatry is lesser known. METHODS:...
IP International Journal of Forensic Medicine and Toxicological Sciences
January 3, 2020
Mohd Kaleem Khan, Jamal Azmat, Faiz Ahmad
A case of self slitting of throat as a result of cannabis induced psychosis - IJFMTS- Print ISSN No: - 2581-9844 Online ISSN No:- 2456-9615 Article DOI No:- 10.18231/j.ijfmts.2019.034, IP International Journal of Forensic Medicine and Toxicological Sciences-IP Int J Forensic Med Toxicol Sci
Journal of Mental Health
January 2, 2020
Ashley M. Schnakenberg Martin, Paul H Lysaker
Abstract Background: While previous research suggests that active cannabis use is a barrier to the emotional experiences of anticipating pleasure and expressing emotion in early psychosis, the relationship between lifetime cannabis use, emotional experience and social function over time has been understudied. Aims: This study sought to characterize the influence of lifetime cannabis use on...
Journal of dual diagnosis
January 2, 2020
Lucia Sideli, Harriet Quigley, Caterina la Cascia et al.
Abstract Objective: This review discusses the relationship between cannabis use and psychotic, bipolar, depressive, and anxiety disorders, as well as suicide. It summarizes epidemiological evidence from cross-sectional and long-term prospective studies and considers possible etiological mechanisms. Methods: Systematic reviews and methodologically robust studies in the field (from inception to...
Yakugaku Zasshi
2020
Masahiko Funada, Ken-Ichi Tomiyama
Cannabis use among the younger population in Japan has been steadily increasing. The aim of the present review is to highlight recent knowledge regarding the molecular mechanisms of action and health risks associated with cannabis and synthetic cannabinoid consumption. We investigated the effects of Δ9-tetrahydrocannabinol (THC) and synthetic cannabinoids on place conditioning in ICR mice. Both...
2020
Maitane Oscoz-Irurozqui, Maria Guardiola-Ripoll, Carmen Almodóvar-Payá et al.
Objectives. To evaluate the association of cannabis use, genes of the endocannabinoid system and their interaction on clinical symptoms and cognitive performance in patients with a first-episode of pyschosis. Background. The role of both cannabis use and individual genetic background has been shown in the risk for psychosis. However, the influence of cannabis and variability at endocannabinoid...
2020
A. Selamoglu, A. Malinowska, George Savulich et al.
Abstract This chapter reviews the literature on the effects of adolescent cannabis use on cognition, wellbeing and the neuroethical implications for societies across the globe. Given its widespread use and availability, cannabis use in adolescence may impact the developing brain, manifesting in cognitive, psychiatric, academic and social changes, thus raising neuroethical concerns. We review...
Revista Brasileira Multidisciplinar
2020
Gabriela Araújo Lemos Cabral, Thays Rodrigues Lelis Curi, Narhima Ahdlie Bou Abbas et al.
Na última década, houve um aumento no aparecimento de transtornos psicóticos e o número de internações pelo uso de Cannabis, popularmente conhecida como maconha. Droga ilícita mais utilizada no mundo, a maconha já foi utilizada por cerca de 9 em cada 100 brasileiros. Seu consumo ocorre na maioria das vezes através do fumo, mas também pode ser através de alimentos, chás e cápsulas. Correlacionar...
European Psychiatry
2020
Valérie M. Moulin, Luis Alameda, David Framorando et al.
22 citations
BACKGROUND: Although evidence from psychosis patients demonstrates the adverse effects of cannabis use (CU) at a young age and that the rate of CU is high in subgroups of young violent patients with psychotic disorders, little is known about the possible effect of the age of onset of CU on later violent behaviors (VB). So, we aimed to explore the impact of age at onset of CU on the risk of...