Innovative therapies, such as psilocybin-assisted psychotherapies, hold great promises for treating anxiety, depression, and various other mental health disorders, addressing some of the challenges faced by conventional psychiatric medicine. This study focuses on developing and validating an HPLC-DAD methodology for detecting psilocybin and psilocin in extracts from psychedelic mushrooms...
Psychological ServicesJuly 10, 2025Rachel L. Dyer, Katherine M Zimmerman, Xinxuyang Zhao et al.2 citations
In recent decades, depression and anxiety have worsened among American adults. Meditation apps may provide an accessible route for reducing these symptoms. However, many users experience barriers to persisting in their use of these apps. Prior research has identified psychosocial and practical barriers and facilitators to the use of meditation apps, as well as barriers and facilitators related...
Schoolteachers are considered as one of the most stressful professions worldwide. This study aimed to investigate the effect of brief mindfulness meditation practice via video streaming on schoolteachers' mental health. Public school teachers were recruited through paper flyers and relevant social media. Participants were randomly assigned to either the meditation or the control group. Blind...
Online mindfulness may be an effective non-pharmacological mental health intervention. To evaluate the effectiveness of an online mindfulness platform in ameliorating anxiety, depression, and stress in patients with chronic diseases. In this randomized controlled study, 97 patients were enrolled and randomly assigned to either the online intervention group (N = 47) or the control group (N =...
The high anxiety rate among students, especially prospective teachers, is a significant concern in higher education. Unmanaged anxiety can negatively affect quality of life, academic performance, and professional competence. This study aims to evaluate the effectiveness of Mindfulness-Based Stress Reduction (MBSR) in reducing state and trait anxiety among undergraduate students in education...
Mindfulness interventions for test anxiety in a college student population are beneficial. This study expands on the existing literature by examining how online mindfulness practices may help alleviate anxiety and test anxiety in college students utilizing a waitlist control group (WLC). This study assessed the effects of online mindfulness practices over a five-week period on anxiety and test...
Psilocybin, also known as “magic mushrooms,” is naturally found in psychedelic compound from different types of mushrooms. The utility of psilocybin for spiritual and therapeutic purposes has already go through several centuries. Scientific research on these compounds gained traction in the mid-20th century, the increasing interest in the possible therapeutic benefits of psilocybin has led to...
Mindfulness interventions are indicated to be effective in reducing psychological symptoms faced by patients with cancer. However, there is a lack of revised evidence on their effectiveness during the active treatment phase. To address this research gap, we conducted a meta-analysis of controlled clinical trials with adult patients written in English, published in PubMed, Web of Science,...
ABSTRACT This study examined changes in mindfulness and social anxiety among university students diagnosed with social anxiety disorder, as well as the persistence and underlying mechanisms of these changes following Mindfulness-Based Cognitive Therapy (MBCT). Using an exploratory sequential mixed-methods design, quantitative results were complemented with qualitative insights. From 511...
Pediatric cardiologyJuly 2, 2025Vicki A Freedenberg, Rachel Steury, Robert Podolsky et al.
Adults with congenital heart disease (ACHD) have high rates of anxiety and depression. Strategies to manage the stress of having a chronic disease, improve coping skills and resilience can reduce these rates. To examine the effectiveness of an ACHD-specific, real-time virtual mindfulness-based behavioral intervention (MBBI) on mental health and resilience. A randomized wait-list control study...
Background and Purpose: Anxiety disorders in children are among the most prevalent mental health issues, with widespread negative impacts on their emotional, cognitive
Mindfulness interventions have gained empirical support for treating anxiety. This study investigated the benefit of adding anxiety-specific practice to a mindfulness intervention for anxiety symptoms in young adults. A pre-post design was used with 117 undergraduate students to compare three interventions: a mindfulness intervention with anxiety-specific practice, a conventional mindfulness...
Abstract Objectives The purpose of this study was to assess feasibility and acceptability of a stroke-specific mindfulness-based intervention called Helping Ease Anxiety and Depression after Stroke (HEADS: UP). Method This study was a mixed-methods pilot randomized controlled trial comparing HEADS: UP to treatment as usual (TAU). HEADS: UP is a 9-week mindfulness intervention for stroke...
The transition to work after maternity leave creates anxiety in mothers, which elevates cortisol levels that decrease milk production and lead to early breastfeeding termination. The intervention of mindfulness helps mothers develop awareness while creating positive emotions. This study aimed to analyze the effectiveness of mindfulness in reducing anxiety and increasing self-efficacy among...
Introduction Inflammation has been implicated as an underlying pathology in negative affect and sleep disruption. Cannabinoids like delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) have demonstrated anti-inflammatory properties. This study aimed to assess if cannabis use altered cytokine concentration and whether inflammatory status moderated the influence of 4 weeks of cannabis use on...
Adolescent-onset cannabis use confers higher risk for neuropsychiatric disorders, implicating amygdala dysfunction. However, the mechanisms that mediate Δ9-tetrahydrocannabinol (THC)-triggered neuroadaptive changes in the maturing amygdala remain unclear. Proteomic analysis of amygdala tissue from male adolescent Saimiri boliviensis nonhuman primates chronically treated with THC provided leads...
Menopause is associated with significant physical, psychosocial, and emotional changes that can negatively affect women's quality of life (QoL). In response to this, psychological interventions like mindfulness-based interventions have shown promise in alleviating menopausal symptoms and improving psychological well-being. A comprehensive randomized controlled trial was conducted from May to...
Anxiety disorders are often characterized by excessive sympathetic activation and dysfunction. While breathing relaxation reliably reduces anxiety by dampening sympathetic activity and enhancing parasympathetic tone, the autonomic signatures underlying positive emotion interventions, such as savoring meditation, remain less understood. In this pilot randomized controlled trial, we recruited 44...
Mindfulness-based interventions may contribute to the mental health status and well-being of nurses. Current results are inconsistent, and there are no systematic review and meta-analyses for intensive care unit (ICU) nurses. The aim of this study was to assess the effectiveness of mindfulness-based interventions on psychosocial well-being and occupational-related outcomes among nurses in the...
This pilot study explored the potential of microdosing 1-cyclopropionyl-d-lysergic acid diethylamide (1cp-LSD) to treat canine anxiety. A single-case study was conducted on a 13-year-old female dog with severe separation anxiety, who was treated with 5 µg of 1cp-LSD every 3 days for a month. Anxiety was assessed before, after, and 1 month following treatment using a validated questionnaire. The...