Chronic anxiety is a widespread mental health condition often rooted in deep-seated subconscious beliefs, emotional patterns, and unresolved experiences. This article presents an integrative therapeutic approach that combines clinical hypnotherapy, Rapid Transformational Therapy (RTT), yoga practices, breathwork, and quantum healing principles to address anxiety at cognitive, emotional,...
Background: Childhood anxiety and stress are increasingly prevalent issues worldwide, having effects on cognitive growth and emotional health. Although standard interventions are available, greater interest is being sparked in culturally sensitive, non-invasive approaches. This research investigated the application of Buddhist meditation practices to alleviate stress and anxiety in children...
This study aims to investigate the mediating role of self-esteem in the relationship between mindfulness and trait anxiety during early adolescence. The research sample was selected using a convenient sampling method and comprised students attending 5th, 6th, 7th, and 8th grades in a private secondary school in Izmir during the 2020-2021 academic year. A total of 344 adolescents (221 girls, 123...
OBJECTIVE: This review explores ketamine's expanding role in managing both chronic pain and mental health conditions, focusing on its pharmacologic mechanisms, clinical applications, and therapeutic potential. We assess its analgesic properties, FDA-approved application in the form of Spravato (esketamine) for depression, and off-label use for analgesia and psychiatric disorders. METHODS: A...
Anxiety and depression are highly prevalent mental health disorders, imposing significant burdens on individuals and healthcare systems. Mindfulness-based cognitive therapy (MBCT) has demonstrated effectiveness in reducing these symptoms. Electronic health MBCT (eMBCT) offers a scalable alternative, but its efficacy in alleviating anxiety and depression in adults remains unclear. To examine the...
The current trial aimed to assess the effectiveness of Mindfulness-Based Stress Reduction training on salivary cortisol and α-amylase levels, anxiety and depression of students. This research was an experimental trial with a pre-test-post-test design and a control group. The statistical population of the research included all students studying in the universities of Khoy, Iran in 2021. The...
PharmacyJuly 21, 2025Paula S C C Castro, Kae Leopoldo, Maria Olivia Pozzolo Pedro et al.2 citations
Objective: To systematically review the scientific literature on lysergic acid amide (LSA), focusing on its physical, neurobiological, and social effects, as well as its potential risks and therapeutic uses. Methods: A systematic review was conducted across PubMed, Google Scholar, and Web of Science up to December 2023, using keywords such as "ergine," "lysergic acid amide," and "legal high."...
Depression during pregnancy is often overlooked and undertreated. Ketamine has been shown to exert prompt and sustained antidepressant effects in patients with depression, although concerns of potential neurotoxicity prohibit its use in pregnant women. Here, we aim to investigate the neurobehavioral effects of subanesthetic ketamine on pregnant mice and their offspring. We found that pregnant...
Background: The present study investigated the sustained effects of a 5-week EmotionCore mindfulness training program on emotion regulation, emotional intelligence (EI), trait mindfulness, depression, and anxiety among 120 undergraduates, while exploring the mediating mechanisms of training effect and heterogeneous effects across subgroups. Methods: Participants were randomly assigned to a...
Ketamine’s rapid action and diverse physiological effects have made it an important drug in both anesthesia and mental health treatment. Clinically, it offers unique dissociative anesthetic properties, preserving stable vital signs during sedation and analgesia. Beyond its numbing effect, studies explore its influence on N-methyl-D-aspartate (NMDA) receptors and wider neurochemical systems...
A recent study published in Neuron by Tiwari et al . identified the critical role of 5-HT 2A receptor in ventral hippocampal parvalbumin (PV) interneurons (INs) in mediating the acute anxiolytic effects of the serotonergic psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI). This study not only advances psychedelic neuropharmacology but also provides a robust framework for developing novel...
Anxiety symptoms are highly prevalent among Chinese university students, significantly impairing psychosocial functioning. Although mindfulness has been identified as a protective psychological factor, the precise mechanisms underlying its association with anxiety symptom alleviation remain insufficiently understood. This study investigates the serial mediation effects of rumination and...
Cerebrolysin (CBL), a peptide derived from pig brain, is recognized for its neuroprotective and anti-inflammatory properties. This research aimed to investigate the effects of CBL on anxiety- and depression-like behaviors, spatial memory, the tryptophan/kynurenine (TRP/KYN) pathway, and inflammation in the prefrontal cortex (PFC) of a mouse model for schizophrenia. Thirty-six male BALB/c mice...
Current microbiologyJuly 15, 2025Gokul Sudhakaran, Shreya Chakraborty, Ashok Kumar et al.2 citations
Psilocybe species, commonly known as "magic mushrooms", are a group of hallucinogenic fungi known for their psychoactive compounds such as psilocybin, psilocin, baeocystin, and norbaeocystin. These species have been the focus of scientific study due to their potential therapeutic applications, despite their classification as controlled substances in many jurisdictions. This review aims to...
NeuropsychopharmacologyJuly 15, 2025Maria Beatriz Bistue Millón, Laura Noguera, Diana Bruno et al.4 citations
This Phase I clinical trial is the first to rigorously evaluate the safety, tolerability, and pharmacokinetics of a novel sublingual formulation of 5-MeO-DMT, administered at sub-psychedelic doses to adults with moderate to high levels of anxiety and/or depression, without formal psychiatric diagnosis or ongoing treatment. Using a double-blind, placebo-controlled design, participants received a...
Previous studies have found that self-compassion and mindfulness are negatively related to depressive and anxiety symptoms. Still, the mechanisms underlying these relationships in major depression and whether such mechanisms differ in healthy people are poorly understood. In the present study, it was examined whether mindfulness and worrying mediated relationships between self-compassion,...
Mindfulness-based interventions have provided consistent benefits for the physical and emotional wellbeing of cancer patients. However, their feasibility has not been examined in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT), particularly in the post-transplant phase. The aim of this study was to examine the feasibility and acceptability of a six-week group-based...
Given the high prevalence of psychological complications during pandemics such as COVID-19, it is imperative to identify effective psychological interventions that can improve the mental health of patients and community members. The effectiveness of mindfulness-based intervention in discharged patients with infectious respiratory diseases, particularly during pandemics, has been examined in a...
The brain mechanisms underlying patient improvement after interventions remain poorly understood. Identifying the shared and distinct neural pathway between improvement mechanisms across distinct treatment modalities might improve our understanding of brain-behavior relationships and inform personalized approaches. To investigate the neural correlations of symptom improvement in Generalized...
MedicineJuly 11, 2025Liyuan Fu, Minghui Mao, Chengkun Hong et al.
This study evaluates the influence of solution-focused approaches combined with mindfulness-based stress reduction (MBSR) on claustrophobia in a high-risk cohort undergoing magnetic resonance (MR) imaging. In the prospective observational 2-group study, a total of 77 patients (55% male, mean age 50.1 ± 11.9) underwent solution-focused brief therapy (SFBT) and MBSR before MR examination. The...