British Journal of Pharmacology
August 1, 1979
G. Curzon, J.c.r. Fernando, Andrew J. Lees
66 citations
The roles of catecholamine and 5‐hydroxytryptamine (5‐HT) release in mediating backward walking and circling were studied in rats. These behaviours occurred in animals given 15mg/kg intraperitoneally of (+)‐amphetamine (which predominantly releases catecholamines) or either p ‐chloroamphetamine or fenfluramine (which predominantly release 5‐HT). They also occurred when smaller doses of...
Journal of Drug Issues
April 1, 1979
Richard Bunce
Bad trips occurring during psychedelic drug use are analyzed as social rather than pharmacological products. Survey data from psychedelic users show a dramatic decline in bad trips over the period from the mid-1960s through 1975. Several explanations of this phenomenon are considered. Neither pharmacological explanations nor explanations depending on the growth of supportive subcultures of...
Annals of Internal Medicine
March 1, 1979
R. C. Stillman, Robert C. Petersen
38 citations
Editorials1 March 1979The Paradox of Phencyclidine (PCP) AbuseRICHARD STILLMAN, M.D., ROBERT C. PETERSEN, PH.D.RICHARD STILLMAN, M.D.Search for more papers by this author, ROBERT C. PETERSEN, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-3-428 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack...
Brain Research
February 1, 1979
H S Ahn, M H Makman
The influence of D-lysergic acid diethylamide (LSD) and mescaline on adenylate cyclase activity was studied in homogenates of Cebus and rhesus monkey anterior limbic cortex (ALC), frontal cortex (FC), caudate nucleus and retina. Previous studies have shown these tissues to contain dopamine-stimulated adenylate cyclase (AC). In addition, we are now reporting the presence of a dopamine-sensitive...
Psychopharmacology
1979
R. Malcolm Stewart, Alexander Campbell, Günther Sperk et al.
43 citations
Muscle twitches and autonomic changes were induced by systemic injections of L -5-hydroxytryptophan (5-HTP) or the serotonin agonist 5-methoxy- N,N -dimethyltryptamine (5-MeO-DMT) in rats previously lesioned with intracranial 5,7-dihydroxytryptamine (5,7-DHT) after desmethylimipramine. Movements were recorded sensitively and continuously by an electronic activity monitor. Spontaneous locomotor...
Psychopharmacology
1979
Claudio Castellano
8 citations
The effects of mescaline and amphetamine were investigated in BALB/cJ (BALB) and C57BL/6J (C57) mice using the five-choice Yerkes--Thompson Bryant--Bovet-Nitti apparatus for patterns discrimination. Two sets of experiments were carried out. In the first set, pretrial administration of mescaline (5, 10, and 20 mg/kg) was followed by performance improvements in the C57 mice, while performances of...
Journal of Clinical Psychology
April 1, 1978
G L Gerber
Investigated the proposition that effectiveness of coping with daytime and dream stress would be influenced by personality style, as defined by the Repression-Sensitization scale (R-S), and by dreaming style, as defined by frequent (F) or infrequent (I) questionnaire dream recall. The relationship between R-S and F-I dream recall also was explored. Ss kept dream diaries for 30 consecutive days....
Pharmacology, Biochemistry, and Behavior
April 1978
N S Shah, M P Hedden
Behavioral aspects and metabolic fate of N,N-dimethyltryptamine (DMT) were studied in mice pretreated with beta-diethylaminoethyl-diphenylpropylacetate (SKF 525-A), iproniazid or chlorpromazine (CPZ). DMT at doses of 2.5, 10.0, and 25.0 mg/kg produced several behavioral changes in a dose-related manner: inhibition of spontaneous locomotor movement, enhanced fright responses to sound stimuli,...
European Journal of Pharmacology
November 15, 1977
Om D. Gulati, Nandkumar S. Shah
The amine releasing action of mescaline was investigated in rat isolated hypothalamus labeled with 3H-metaraminol. Mescaline had no effect on the uptake of 3H-metaraminol but produced its release in a concentration-related manner. 4 x 10(-4) M mescaline, which produced submaximal effects was used for subsequent experiments. 3 x 10(-5) M cocaine had no effect on the 3H-metaraminol releasing...
American Journal of Psychiatry
November 1, 1977
67 citations
Phencyclidine appears to be unique in action compared with other psychedelic drugs, and its effects are less dependent upon the individual's personality than are the effects of LSD or mescaline. The authors discuss the sensory, psychological, and behavioral symptoms of phencyclidine intoxication. Most cases are of short duration and the only treatment necessary may be observation together with...