James Thurbon, Annabelle Mitchell, Jordan J Wehrman et al.
preprint
Flicker light stimulation shows promise for inducing visual imagery, altered states of consciousness, and changes in arousal, with potential applications in relaxation and imagery-based therapeutic interventions. However, optimal utility depends on identifying how viewing conditions shape subjective and physiological outcomes. We examined whether eye condition (open, closed) modulates...
Laxna Bhujel, Angela L. Chiew, Bhashita Jagarlamudi et al.
Aims: Recreational nitrous oxide (N 2 O) misuse is a growing problem. It can cause functional hydroxycobalamin (B 12 ) deficiency and severe neurological complications. Despite increasing harms, the dose-response relationship and clinical value of biomarkers remain unclear. This study aimed to characterise the demographics, patterns of use, outcomes, and biomarker utility in patients...
Uri Bright, Suhas Ganesh, Daniel F. Levey et al.
Abstract Background Cannabis is one of the most widely used psychoactive substances worldwide. Δ 9 -tetrahydrocannabinol (Δ 9 -THC) is the main contributor to cannabis-induced effects such as euphoria, anxiety, and psychotomimetic effects, and is metabolized by several hepatic enzymes, including CYP3A4. There are interindividual differences in how cannabis affects users, which have substantial...
Richard Clark Kaufman
preprint
Background: A person with depression, unresolved trauma, a substance problem, and cognitive complaints is treated differently depending on which practitioner they consult. A psychiatrist draws on the monoaminergic and glutamatergic literature. A licensed facilitator draws on the session literature. A naturopath draws on the botanical and nutritional literature. Each draws on a defensible...
Sarah Roche, Kim Pc Kuypers, Joana Wensing et al.
preprint
The therapeutic and societal promise often attributed to psychedelic drugs implies meaningful change in real-world behaviour, yet such change is rarely measured directly. Across psychedelic research, outcomes are typically assessed using symptom scales, self-reported psychological states, or retrospective judgments of change, which may capture subjective improvement but do not by themselves...
Amanda E. Downey, Ellen Bradley, Daniel Dickison et al.
preprint
Psychedelic-assisted psychotherapy is generating substantial clinical interest, yet despite growing economic scrutiny, a practical question has received surprisingly little attention: how do specific delivery decisions drive cost? Labor costs—typically the dominant cost component of psychedelic therapy delivery—depend on a tangle of interacting design choices: the number, length, and staffing...
Ziming Li, Crystal Weber, Francesca Sellitti et al.
Abstract A single dose of psilocybin can induce long-lasting antidepressant effects. The neurobiological mechanisms underlying such sustained antidepressant effect remain insufficiently understood, particularly at the level of synaptic function and drug-target specificity. Here, we aimed to delineate single-dose psilocybin-induced excitatory synaptic plasticity. Synaptic plasticity was assessed...
Michael Sarvi, Aryan Sarparast
preprint
Abstract Background State-regulated psilocybin services have expanded access outside research settings. Patients seeking these services may have medical and psychiatric complexity not represented in clinical trials, while guidance for clinicians advising them remains limited. We introduce the Psilocybin Education and Assessment Collaborative for Excellence (PEACE), a consultation model within a...
G Samuelson
preprint
Dreaming is among the most vivid demonstrations that consciousness can occur in a state of relative sensory disconnection. This paper reviews whether dream experience is better explained as an endogenous neurocognitive construction or as evidence of contact with another dimension, multiverse branch, or anomalous informational domain. The review integrates literature from the neuroscience of REM...
Isha Bhola
preprint
This article is a review of the paper Consciousness and Cognitive Science by Henrique Schutzer Del Nero and Jose Roberto Castilho Piqueira. The paper proposes a model for consciousness based upon the hypothesis: a) the core of human cognition is consciousness and b) the Theory of Dynamical System furnishes a good conceptual tool to endorse a project that compatibilizer reduction and the...